Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Hypoxemia"”.
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Effects of Long-Term, High-Altitude Hypoxemia on Fetal Ovine Coronary Arteries
… the effects of long-term, high-altitude hypoxemia on the contractility of fetal coronary vessels, namely the left circumflex, left anterior descending, and right coronary arteries. We have found that in response to chronic hypoxia, isolated fetal ovine coronary arteries exhibit attenuated …
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Effects of emphysema and chronic hypoxemia on skeletal muscle oxygen supply and demand
… conducted to test the hypothesis that chronic hypoxemia leads to alterations in oxygen transport and muscle function. A primary objective was to validate elastase-induced emphysema in rats as an animal model of skeletal muscle dysfunction in COPD.Arterial blood gases were used to determine the …
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Validation of tissue oxygen saturation determined by near-infrared spectroscopy in canine models of hypoxemia and hemorrhagic shock
The objective of this study was to evaluate the relationship between tissue oxygen saturation (StO2) and oxygen delivery index (DO2I). Oxygen delivery index is product of two factors arterial oxygen content (CaO2) and cardiac index (CI). In this study the relationship between DO2I and StO2 was …
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Effect of Long-Term Hypoxia on Myocardial Alpha1- Receptors
… the effect of long-term high-altitude hypoxemia on the α<sub>1</sub>- and β<sub>1</sub>-adrenergic receptor interaction in the heart. The interactions between two receptor systems were examined by prior stimulation of muscles with α<sub>1</sub>-adrenergic agonist phenylephrine (PHE). …
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An exploratory study of neuropsychological impairment, driving performance, and sleepiness in obstructive sleep apnoea and chronic obstructive pulmonary disease
… arousals during sleep, and/or the degree of hypoxemia and oxygen desaturation. In contrast, the level of impairment seen in COPD is related to the degree of hypoxemia both during sleep and during waking hours. The major aim of this study was to compare driving performance and …
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Brain Injury and Inflammation and Placental Inflammation in Response to Repetitive Umbilical Cord Occlusions in the Near Term Ovine Fetus
… injury, which will be exacerbated by chronic hypoxemia and low-grade infection. Chronically instrumented fetal sheep served as controls or underwent repetitive UCOs for up to 4 hours or until fetal arterial pH was2saturation pre-UCOs of >55% and
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ΜΕΛΕΤΗ ΤΩΝ ΣΧΕΣΕΩΝ ΑΕΡΙΣΜΟΥ/ΑΙΜΑΤΩΣΗΣ (VA/Q), ΤΟΥ ΠΝΕΥΜΟΝΑ ΜΕΤΕΓΧΕΙΡΗΤΙΚΑ ΚΑΙ ΟΙ ΜΕΤΑΒΟΛΕΣ ΤΟΥΣ ΑΠΟ ΤΗΝ ΚΑΘΙΣΤΙΚΗ ΘΕΣΗ
… THAT POST-OPERATIVE PULMONARY DYSFUNCTION AND HYPOXEMIA IS MAINLY CAUSED BY A SHUNT LIKE EFFECT.SITTING POSITION IMPROVES PULMONARY GAS EXCHANGE IN PATIENTS WITH VA/Q INEQUALITIES. SITTING POSITION DOES NOT REDUCE THE TRUE INTRA PULMONARY SHUNT BUT INCREASES ALVEOLAR VENTILATION THUS DECREASING …
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Evaluation of clinical methods of pulmonary gas exchange assessment in the standing horse
… Albuterol caused significant (p<0.05) hypoxemia 15 minutes following inhaled administration. This was accompanied by a significant increase in Q<sub>S</sub>/Q<sub>T</sub>, suggesting that the hypoxemia was due to increases in which the ratios of ventilation to perfusion were decreased.
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A norm- and control-referenced comparative study of the neuropsychological profiles of shift workers and patients with obstructive sleep apnoea (OSA)
… The possibility arises that intermittent hypoxemia and sleep deprivation due to sleep fragmentation in OSA and sleep deprivation secondary to sleep cycle disruption in shift work may underlie neuropsychological deficits, which in turn meditate these functional impairments. The current …
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Effects of hypervolemia on arterial oxygenation in thoroughbred horses performing exercise simulating the second day of a 3-day equestrian event
… Leon et al. 2002). Exercise induced arterial hypoxemia is not typically seen during moderate exercise in normal horses and hyperhydration (and hypervolemia) does not affect arterial oxygen tension or hemoglobin saturation during short term maximal exertion (Manohar et al. 2003). Studies were …
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Neuropsychological Sequelae of Obstructive Sleep Apnea in Later Adulthood
… indicated executive functions were related to hypoxemia and sustained attention was related to sleep fragmentation in the current study. A medical sequelae model and a neuropsychological sequelae model were tested. The neuropsychological sequelae model predicted whether one was a control or an …
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Canine cardiopulmonary responses to one-lung ventilation during thoracoscopic diaphragmatic incision repair and two-lung ventilation during gasless laparoscopic diaphragmatic incision repair
… may predispose to an increased risk of hypoxemia when compared to left lung collapse with right lung ventilation;(2) Two video-assisted surgical techniques are described for the repair of diaphragmatic incisions: (a) gasless laparoscopy with an abdominal lifting device and (b) …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… alveolar damage, pulmonary edema, and severe hypoxemia, with limited therapeutic options. Increasing evidence identifies endothelial dysfunction and vascular barrier disruption as central drivers of ARDS pathogenesis, particularly in the context of SARS-CoV-2 infection. This thesis …
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Tissue enzyme changes in air-exposed American eels.
… that the eel suffers from acidosis and hypoxemia as a result of this air exposure, but the survival of the eels despite these conditions demonstrates a large degree of tolerance to these effects. This thesis will investigate the changes in tissue enzymes of the American eel as a result …
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Serum calcitonin gene-related peptide concentrations in the horse and their relationship to the Systemic Inflammatory response
… fungal or parasitic invasion or from trauma or hypoxemia. Local and systemic release of a wide variety of endogenous pro-inflammatory mediators results in activation of the innate immune system in order to resolve the insult. In sepsis this initial appropriate host response becomes amplified and …
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Exercise response and the effect of supplemental oxygen during interval training on O2 uptake kinetics, blood lactate levels, and endurance performance in patients with mild, moderate and severe cystic fibrosis
… A ventilatory mechanical limitation, arterial hypoxemia, cardiovascular abnormalities, alteration in O2 uptake kinetics and reduced muscle strength may contribute to the reduced exercise performance in individuals with CF patients. The purpose of this research was to compare the exercise …
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The Physiological Function of Endothelin-2 in Mice
… of total lung capacity, resulted in chronic hypoxemia, hypercapnia, and increased erythropoietin synthesis. Finally, to rule out effects of ET-2 during embryonic development, I used the Cre-loxP system to delete ET-2 in neonatal and adult mice, and found that these mice fully reproduced the …
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Identification of novel coding single nucleotide polymorphisms associated with acute respiratory distress syndrome
… of inflammatory mediators, causing inflammation, hypoxemia and multiple organ failure. Disease susceptibility and progression are poorly understood and there are few effective therapeutic options. Existing biomarkers have limited effectiveness as diagnostic and therapeutic targets. Whole-exome …
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Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury
… and pulmonary infiltrates. Moderate ALI causes hypoxemia, leading to respiratory failure if left unattended. Patients with severe ALI develop acute respiratory distress syndrome and require supplemental oxygen or mechanical ventilation. Despite advances in critical care, mortality from ALI is …
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Obstructive Sleep Apnea and the Effects of Co-Existing Factors on PACU Stay Time
… recovery, increased apneic episodes, hypoxemia, and death. Examining duration of recovery periods between the two OSA groups will help determine if patients with additional cofactors benefit from longer post-operative monitoring or modification of anesthetic technique. Methods: An …
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