Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 426 for “"microglia"”.
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TGFβ signalling in microglia and the impact of microglia-specific Smad4 deletion
… growth factor-β (TGFβ) signalling in microglia and the regulation of Smad4-mediated microglial functions, and their subsequent impact on central nervous system (CNS) homeostasis, neurodevelopment, and neuroinflammation. The study comprehensively describes the TGFβ signalling pathway in …
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MICROGLIA-SUFFICIENT BRAIN ORGANOID
… colonize the brain where they differentiate into microglia. Microglia were shown to contribute to brain development in animal models but their roles in human brain development remain poorly understood due to the lack of tissue access. The generation of brain organoids from induced human …
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Novel Tools for Investigating Microglia Cellular Turnover Kinetics and Microglia-CD4 T Cell Interaction
SUMMARY Under homeostatic conditions microglia maintain a tightly-controlled population size, contributing to 5-12% of cellular tissue in the mouse brain, depending on brain region. Following injury and under inflammatory conditions microglia undergo microgliosis, a rapid expansion in number and …
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Microglia-Mediated Neuroprotection from Concussion
… and resultant recovery monitoring strategies. Microglia are brain-resident immune cells and homeostatic regulators of brain function, playing a key role in cognitive outcome following neurological disease. Yet, we have few means of surveilling brain-specific inflammation. Emerging techniques …
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Mechanisms of microglia induced retinal degeneration
… patientswith retinal neurodegenerative diseases. Microglial activation is known to play animportant role in neuroinflammation and neurodegeneration. However, there is adebate on whether microglial activation is the primary cause or a consequence ofretinal neurodegeneration. It is also unclear why …
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
Microglia are resident innate immune cells of the central nervous system with potent phagocytic and inflammatory capabilities. These cells are crucial in both health and disease, including neurodegenerative diseases. Genetics studies have linked Alzheimer’s disease and other diseases to genes that …
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Evaluating Microglia Dynamics in Blast and Impact-Induced Neurotrauma and Assessing the Role of Hemostatic Nanoparticles in Microglia Activation
… disparities has yet to be elucidated. Microglia dynamics play a key role in initiating the inflammatory response after injury, as microglia become activated by undergoing morphological changes that influence their function in the injured brain, and unique signaling pathways influence …
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Adult Human Microglia: Phenotypic Diversity and Functional Complexity
… system (CNS) throughout health and disease. Microglia are the resident immune cells of the CNS. Present throughout the brain parenchyma and in constant communication with the peripheral immune system, microglia are essential regulators of brain physiology. The adult human brain is prone to …
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LRRK2 Regulates Actin Dynamics in ADP-Treated Microglia
… neuronal death in the substantia nigra. Microglia are brain macrophages that continuously survey the microenvironment of the brain to find out and repair brain damage. Although PD associated genes are expressed in microglia, their roles in these cells are largely unknown. The present …
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Investigating the role of microglia in myelin development
We investigate the role of microglia in myelin development. Myelination is an essential process in early development that consists of the ensheathment of axons by myelin, which ensures rapid conduction of action potentials. Although myelination is predominantly driven by oligodendrocytes, the other …
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Microglia and Myelin: Improved Tools and Molecular Interactions
… also implicate additional cell types including microglia as providers of important molecular cues in myelination. Studies dissecting these cues have made great strides, yet the functions of many candidate molecular mediators remain incompletely defined, at least in part due to the scarcity of …
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The Diversity of TLR4-triggered Responses in Mouse Microglia
Mikroglia repräsentieren den vorherrschenden Immunzelltyp im ZNS. Während der steten Überwachung der Mikroumgebung sind diese Zellen jederzeit bereit, vom ruhenden in einen aktivierten Status zu wechseln. Dies geschieht insbesondere nach dem aufspüren von "Gefahr"-assoziierten Signalen, wie dem …
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The Transcriptional Profile of Microglia: From Brain to Dish
The Transcriptional Profile of Microglia: from Brain to Dish Fiona Elizabeth Calvert Microglia are the tissue resident macrophages of the central nervous system (CNS) and multiple lines of evidence indicate that microglia are a pathogenic cell type in Alzheimer’s disease (AD). It is important to …
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Gamma frequency entrainment attenuates amyloid load and modifies microglia
… expression profiling revealed an induction of microglia specific genes associated with morphological transformation of microglia and increased A[beta] phagocytosis by microglia. Inspired by these observations, we designed a non-invasive light-flickering paradigm that induced 40 Hz activity in …
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Effects of carnosine in experimental models of neuroinflammation: focus on human microglia [Effetti della carnosina in modelli sperimentali di neuroinfiammazione: focus sulla microglia umana]
La microglia, le cellule immunitarie del cervello, sono essenziali per lo sviluppo del cervello, la plasticità sinaptica e la neurogenesi, essendo responsabili del mantenimento dell'equilibrio eliminando proteine mal ripiegate e cellule morte. La perdita dello stato omeostatico della microglia è …
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Microglia and Complement in Alzheimer's Disease with Cerebral Amyloid Angiopathy
… for clearance. We found more Aβ bound to the microglial CD11b receptor through complement C3b in CAA patients compared to AD and control subjects. Additionally, 75% of CAA patients in this cohort harbor the CAA risk haplotype rs6656401 at the <em>CR1 </em>gene, which seems to modify the …
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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Selektiver Transfer von Exosomen von Oligodendrozyten zu Mikroglia durch Makropinozytose Oligodendrozyten sind die Myelin-bildenden Zellen des zentralen Nervensystems. Dieser Zelltyp bildet während der aktiven Phase der Myelinisierung große Mengen an Zellmembran aus. Zusätzlich werden …
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