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University of New Orleans
Synthesis and Biological Evaluation of Novel GBR 12909 Tropane and Azetidine Hybrid Analogues
Abstract
dc:description.abstractThe high affinity, selective dopamine transporter ligand GBR 12909 has served as a template for the design of two novel classes of dopamine transporter ligands. A series of 3-[2- (diarylmethoxyethyidenyl)]-N-substituted tropane derivatives were synthesized and the binding affinities of these compounds were determined at the dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in rat brain tissue preparations. The tropane derivatives were found to exhibit more potent affinity and selectivity for DAT than GBR 12909. From the SAR of the tropane analogues and GBR 12909, a novel series of 3-[2-(diarylmethoxyethylidenyl)]-Nsubstituted azetidine derivatives has been developed.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Year
- 2007
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Cararas, Shaine A.
- Contributors dc:contributor
-
- Trudell, Mark
- Jursic, Branko
- Tarr, Matthew
Subjects
dc:subject × 6Identifiers
dc:identifier.*- Repository record dc:identifier
- https://scholarworks.uno.edu/td/565
- OAI identifier oai:identifier
- oai:scholarworks.uno.edu:td-1565