Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"SERT"”.
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Modeling of flexible drug-like molecules : qsar of GBR 12909 analog dat/sert selectivity
… binding to the serotonin transporter (SERT) can vary greatly depending on the specific substituents on the molecule. This study uses Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices (CoMSIA) techniques to determine a stable and predictive model …
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Modulation of the Serotonin Reuptake Transporter in RAW264.7 Macrophages
… modulator. The serotonin reuptake transporter (SERT) clears the extracellular space of 5-HT, which decreases the effects of 5-HT on target cells. This study demonstrated that the RAW264.7 macrophage cell line expresses SERT function, measured by assays of 3H-5HT uptake. The 5-HT uptake in …
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Investigating disturbances of brain 5-HT systems by experimental MRI and SPECT neuroimaging
… antidepressants of the serotonin transporter (SERT) would result in alleviated symptoms of depression by enhancing serotonin neurotransmission. Since depression can be treated with antidepressants that target SERT, and a recently discovered 5-HTT gene-linked polymorphic region (5-HTTLPR) of the …
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Mechanisms of platelet inhibition by the selective serotonin reuptake inhibitor citalopram
… (5-HT) uptake by the serotonin transporter (SERT). Since blood platelets express SERT, SSRIs may modify platelet function and the risk of cardiovascular disease. However, the beneficial or adverse effects of SSRIs on arterial thrombosis are poorly characterised and detailed in vitro …
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Characterization of an Evolving Serotonin Transporter Computational Model
… of a central target, the serotonin transporter (SERT). Established SERT inhibitors (SSRIs) were docked to an in silico SERT model to identify likely binding pocket amino acid residues. When mutated singly, no one of five implicated residues was critical for high affinity in vitro binding of SSRIs …
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Neurochemical, epigenetic, and structural brain changes associated with prenatal stress exposure, and the mitigating effects of DHA
… polymorphisms in the serotonin transporter (SERT) gene may interact with environmental stress during pregnancy, increasing ASD risk. Offspring of stress-exposed mice with one SERT gene copy missing (SERT-het) exhibited autism-related behaviors, indicating heightened stress susceptibility. …
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
… of the serotonin reuptake transporter (SERT) and the vesicular monoamine transporter 2 (VMAT2) to the physiological, behavioral and neurotoxic responses to MDMA. SERT functions as a primary regulator of 5-HT homeostasis, mediating the reuptake of 5-HT from the synaptic space following …
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Pharmacological Characterization of Novel Serotonin Transporter Inhibitors Identified Through Computational Structure-Based Virtual Screening
… The SSRIs target the serotonin transporter (SERT), a monoamine transporter (MAT) responsible for terminating serotonergic neurotransmission. The SSRIs are not perfect therapeutics and suffer from delayed response times, inconsistent efficacy among patients, and often produce intolerable side …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… that conditional deletion of KOR from Slc6a4 (SERT)-expressing neurons blocked stress-induced potentiation of cocaine conditioned place preference (CPP). Within the dorsal raphe nucleus (DRN), two overlapping populations of KOR-expressing neurons: Slc17a8 (VGluT3) and SERT, were distinguished …
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Synthesis and Biological Evaluation of Rigid Analogues of Methamphetamines
… were determined at dopamine (DAT) and serotonin (SERT) transporters in rat brain tissue preparations. The preliminary in vitro binding studies revealed that the rigid scaffold of the azetidine ring system was an effective substitution for the 2-aminopropyl group of methamphetamine and led to …
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Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)
… binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake inhibitors (SSRIs). A …
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Monoamine Transporter Photoaffinity Ligands Based On Methylphenidate and Citalopram: Rational Design, Chemical Synthesis, and Biochemical Application
… transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Specifically, dysregulation of MAT function is associated with a host of disease states including drug abuse, major depressive disorder, and anxiety. Additionally, several drugs acting as MAT inhibitors …
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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX
… expression of the serotonin reuptake transporter SERT. Maintenance of appropriate 5-HT levels is important for development of these sensory systems. The current study was undertaken to define the effect of developmental Pb exposure on the transient uptake of 5-HT in LSO and thalamocortical neurons …
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THE EFFCT OF LOW-LEVEL LEAD ON SEROTONIN EXPRESSION IN THE DEVELOPING MOUSE SUPERIOR OLIVARY COMPLEX AND SOMATOSENSORY CORTEX
… expression of the serotonin reuptake transporter SERT. Maintenance of appropriate 5-HT levels is important for development of these sensory systems. The current study was undertaken to define the effect of developmental Pb exposure on the transient uptake of 5-HT in LSO and thalamocortical neurons …
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The effects of chronic ethanol self-administration on the serotonin system in monkeys
… processes via the serotonin transporter (SERT) and 5-HT1A receptor. Illuminating the mechanisms underlying the effects of chronic ethanol on the SERT and the 5-HT1A receptor in the hippocampus may help to identify additional targets for the treatment of alcoholism.
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Adversity in early adolescence alters female rats' anxiety-related behaviours and serotonergic innervation profiles in adulthood
… for the serotonin transporter (SERT) in the medial prefrontal cortex (mPFC) and ventral hippocampus. Administration of IPS (i.e., water immersion, elevated platform, foot shock) in early adolescence increased rats’ anxiety-like behaviour in the elevated plus-maze but had no …
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Chimeras and Jagunços: Positivist Discourse in Euclides da Cunha's Os Sertões
… For close to a century Euclides da Cunha's Os Sert\xf5es has been treated as the literary instantiation of mestiço degeneration, a work best classified with the Spencerian 'race science' of Arthur Gobineau and Raimundo Nina Rodrigues. This classification, however, is incorrect. In Os …
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Serotonin transporter import
… of these proteins, the serotonin transporter (SERT) and the dopamine transporter (DAT). Collaborating with Diwakar Shukla’s group at UIUC, we have further advanced the understanding of function in these transporters by performing molecular dynamics simulations with and without various …
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Inflammatory Mechanisms And Vulnerability For Major Depression: From Animal Models To Drug Treatment
… if the deletion of serotonin transporter (SERT) gene, a susceptibility gene for depression, was associated with altered expression of inflammatory markers under basal conditions. Secondly, we investigated the functional consequences of exposing these animals to an inflammatory challenge …
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Synthesis and Biological Evaluation of Novel GBR 12909 Tropane and Azetidine Hybrid Analogues
… determined at the dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in rat brain tissue preparations. The tropane derivatives were found to exhibit more potent affinity and selectivity for DAT than GBR 12909. From the SAR of the tropane analogues and GBR 12909, a novel …
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