Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 692 for “"Dopamine"”.
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
<p>Parkinson’s disease (PD) results from severe dopamine (DA) neuron loss within the substantia nigra pars compacta. In an effort to replace the diminished DA levels, L-dopa, the precursor of DA, is administered. Although the most commonly prescribed medication, the site(s) where L-dopa is …
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Dopamine Uptake Inhibition Potency Fluctuations of Cocaine at the Dopamine Transporter
Cocaine and other dopamine transporter (DAT) inhibitors block synaptic dopamine uptake by binding to the DAT. Cocaine, a powerful psychostimulant, potentiates the dopamine mediated signal transduction in the reward areas of the brain resulting in physical dependence on the drug. Amphetamines are …
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Behaviour disorders dopamine-related
Today there is a growing awareness that in Parkinson's disease can occur motor and non motor disorders, in particular substances dependency syndromes and behavioral addiction. Objectives of the study. Objective of the study is to determine any changes frontal circuits potentially involved in the …
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Dopamine and reward : effects of dopamine antagonist drugs on operant and consummatory behaviours
The Herrnstein matching law was used to dissociate motoric from motivational drug-induced performance changes. The effects of neuroleptic drugs were compatible with, at low doses, a reduction in reinforcer efficacy, and at higher doses, an additional motor impairment However, the Herrnstein …
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Benzodiazepines and Dopamine Mediated Behavior
These studies assess the effects of dopamine depleting lesions on behavior and the effects of benzodiazepines on catalepsy and the ventral tegmental area.
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
… MPH is a psychostimulant that inhibits the dopamine (DA) and norepinephrine (NE) transporters to increase extracellular monoamines. Abuse rates of MPH are increasing as prescription rates increase, but the effects of high-dose, chronic MPH exposure have not been well defined. In particular, …
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Striatal Dopamine Dynamics Upon Manganese Accumulation
<p>STRIATAL DOPAMINE DYNAMICS UPON MANGANESE ACCUMULATION </p> <p>by MADIHA KHALID</p> <p>August 2013</p> <p>Advisor: Dr. Tiffany Mathews</p> <p>Major: Chemistry (Analytical)</p> <p>Degree: Doctor of Philosophy</p> <p>Although manganese (Mn) is fundamental for many biological processes, exposure to …
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COMT Genotype, Schizophrenia, and Dopamine Transmission
… (COMT) catabolism is the primary mechanism for dopamine signal deactivation in the dorsolateral prefrontal cortex, an area of the brain associated with working memory. Working memory deficits are found in persons with schizophrenia and their unaffected siblings. A single nucleotide polymorphism …
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Behavioural microanalysis of dopamine autoreceptor function
Low doses of dopamine autoreceptor (DA) agonists are presumed to act by stimulating DA autoreceptors on the sona/dendrites and axon terminals of DA neurons. Low doses of apomorphine reduced food Intake, in a microstructural analysis paradigm, by reducing both the time spent feeding and the rate of …
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Renal dopamine and salt-retaining states
… generally regarded as a neurotransmitter, dopamine is also known to be secreted by the kidney whereby it promotes sodium excretion in its role as a natriuretic honnone. Peripheral dopamine may be formed by two alternative pathways; the decarboxylation of circulating L-Dopa by L-aromatic …
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Improving dopamine monitoring with NCAM and the effects of intranasal oxytocin on dopamine signaling in the rat brain
<p>Dopamine (DA) is a neurohormone highly involved in learning and memory. Oxytocin (OXT), another neurohormone, has also been implicated in learning and memory. Fast-scan cyclic voltammetry (FSCV) is a method used for the real-time examination of DA neurotransmission in the brain. Implanting FSCV …
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Neuroprotective Effects of FGF20 on Dopamine Neurones
… (FGF20) to have neuroprotective effects on dopamine neurones in vitro. In this thesis, FGF20’s neuroprotective effects on dopamine neurones were further investigated. A ventral mesencephalic (VM) embryonic dopamine neurone culture system and a partially lesioned 6-hydroxydopamine (6OHDA) rat …
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Molecular Characterization of Dopamine Transporter Phosphorylation and Regulation
<p>The dopamine transporter (DAT) is a presynaptic membrane phosphoprotein that terminates dopaminergic synaptic transmission by clearing dopamine (DA) back into presynaptic neuron by a reuptake process. DAT is also a molecular target for psychostimulants such as cocaine, amphetamine (AMPH) and …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
Dopamine receptors are known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these receptors as well. Studies on dopamine receptors in the cardiovascular system …
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The Role of ERK5 in Dopamine Neuronal Survival
… was observed at postnatal day zero (PND0) in all dopaminergic regions, which declined with the postnatal development. However, expression of total ERK1 and ERK2 increased with the postnatal development. An increase in the p-ERK1 and p-ERK2 peak was observed in both dopaminergic cell bodies …
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Dopamine Modulates Corticostriatal Inputs During Motor Command Signalilng
… which to enact. In Parkinson's disease, loss of dopamine levels due to loss of dopaminergic neurons results in unbalanced basal ganglia output and loss of motor control. Motor sequences are thought to be triggered by cortical inputs as these glutamatergic inputs provide the main excitatory drive …
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Sex Differences in Nicotine-Conditioned Hyperactivity in a Model of Dopamine D2 Receptor Priming: Roles of Dopamine D2 and D3 Receptor Subtypes.
… These results suggest differential roles of the dopamine D2 and D3 receptors in both adolescent nicotine sensitization and conditioned activating effects of nicotine.</p>
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