The chemical and enzymatic synthesis of poly(ADP-ribose)

Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are methods for the synthesis of homogeneous poly(ADP-ribose) as well as the biology that is enabled by these synthetic efforts.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2016

Author dc:creator

• Lambrecht, Michael

Contributors dc:contributor

• Hergenrother, Paul J.
• Silverman, Scott K.
• Mitchell, Douglas A.
• Sarlah, David

• Poly(ADP-ribose)
• Total Synthesis
• Enzymatic Synthesis
• Poly(ADP-ribose) Polymerase
• Poly ADP ribose polymerase (PARP)
• Poly(ADP-ribose) Glycohydrolase (PARG)
• Raptinal

Statement dc:rights

• Copyright 2016 Michael Lambrecht

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/92923

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/92923