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Showing 1 to 20 of 457 for “"Adp"”.
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Economic analysis for ADP
This thesis was produced for the Naval Data Automation Command to help increase field analysts capabilities to produce quality economic analyses. The field analyst is introduced to both concepts and methodology. It is tailored to the field analyst's background. Both economic analysis and budgeting …
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Pharmakologie der ADP-Rezeptoren auf humanen Thrombozyten
… lange Zeit auf die Beschreibung als ADP-Rezeptorantagonist beschränkt. Im Zuge neuerer Erkenntnisse zum Mechanismus der Auslösung einer Aggregation, insbesondere der ADP-vermittelten Aggregation, sollte im Rahmen dieser Dissertation der Wirkmechanismus der Thienopyridine genauer …
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Regulation of Protein Degradation by ADP-Ribosylation
… The post-translational modification, poly-ADPribosylation has an estimated half-life of only 1-6 min. My thesis research aimed to reveal how the substrates of Tankyrase are degraded rapidly. Using Drosophila melanogaster, I described the role of Iduna E3 ubiquitin ligase in the regulation …
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Enzymatic synthesis of defined-length poly(ADP-ribose) and the investigation of cell-permeable poly(ADP-ribose) glycohydrolase inhibitors
Poly(ADP-ribosylation) (PARylation) is an important post-translational modification that maintains genomic stability in a cell. Engaging in important cellular processes such as DNA repair and cell death signaling, PARylation has gathered considerable interest as a target for genotoxic chemotherapy …
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Charakterisierung der ADP-Ribosyltransferase CDTa von Clostridium difficile
… Dabei handelt es sich um eine binär aufgebaute ADP-Ribosyltransferase, die mit den binären Toxinen von C. botulinum (C2-Toxin) und C. perfringens (Iota-Toxin) verwandt ist. Die Transferase besteht aus der Enzymkomponente CDTa (48 kDa) und der Binde- und Transportkomponente CDTb (94 kDa). CDTa …
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LRRK2 Regulates Actin Dynamics in ADP-Treated Microglia
… an actin rich structure of moving cells, when ADP induced microglial movement. In immunoprecipation assay, LRRK2 interacted with focal adhesion kinase (FAK), a protein that regulates the adhesion and migration of cells. LRRK2 and FAK were co-localized with ruffles when microglia actively moved. …
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ADP-Heptose and Nucleotide Enhancers Drive Fusobacteria-Induced Inflammation
… secretes pathogen-associated molecular pattern ADP-heptose and ribonucleotides that together, but not individually, strongly induced NF-<em>κ</em>B signaling as well as the expression of inflammation and cancer associated genes. This finding suggests a regulatory role for extracellular …
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ADP regulation of insulin secretion and beta-cell apoptosis
… β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 …
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The chemical and enzymatic synthesis of poly(ADP-ribose)
Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are …
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High-throughput screening for ADP-ribosyl hydrolase 3 inhibitors
Poly(ADP-ribose) (PAR) signaling is an important component of DNA damage repair, DNA replication, and initiation of parthanatos, a method of controlled cell death. While PAR has been well studied for decades, much is still unknown about PAR’s initiation of parthanatos and the importance of …
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Struktur-Funktions-Beziehung der ADP-Ribosyltransferase Clostridium botulinum C2-Toxin
Das Aktin ADP-ribosylierende Clostridium botulinum C2-Toxin ist ein binäres Toxin, das aus der Bindungskomponente C2II und der enzymatischen Komponente C2I besteht. C2I ADP-ribosyliert G-Aktin und depolymerisiert so das Aktinzytoskeletts. In der vorliegenden Arbeit wurde die …
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Chemical Tools to Monitor and Inhibit poly(ADP -Ribosyl)ation
… structure of the complementary enzyme poly(ADP-ribose)glycohydrolase (PARG) is available, and therefore it has been difficult to intelligently design compounds to inhibit this enzyme. To date, the known inhibitors of PARG can be predominantly grouped into the three categories of DNA …
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Biochemische Charakterisierung des ADP-Rezeptors P2Y12 und pharmakologische Therapiekontrolle von Thrombozytenfunktionshemmern
… wie Thrombin, Thromboxan A2, ADP oder Serotonin aus dem Zellinnern. Durch diesen Prozess der Degranulierung können nun weitere Thrombozyten aktiviert werden. Die Sekretion stellt somit einen wichtigen, verstärkenden Schritt in der Aktivierung von Thrombozyten während der …
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Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… cytoplasmic adapter protein. Nuclear enzyme Poly ADP-ribose Polymerase-1 (PARP-1) and the transcriptional repressor Snail-1 work with ILK to downregulate epithelial cell-cell adhesion. This process would also be necessary for proper trophoblast syncytialization. Thus, it was hypothesized that …
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DEVELOPING SMALL-MOLECULE PROBES AND INHIBITORS FOR ADP-RIBOSE-BINDING PROTEINS
… protein adenosine diphosphate ribosylation (ADP-ribosylation) serves as key effectors and regulators in a plethora of biological processes. Although the biological roles of mono-ADP-ribosylation (MARylation) and poly-ADP-ribosylation (PARylation) have been extensively studied, and many …
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Investigating the substrate binding mechanism of the mitochondrial ADP/ATP carrier
Mitochondrial ADP/ATP carriers catalyse the equimolar exchange of ADP and ATP across the mitochondrial inner membrane, providing metabolic energy for the cell. Crystal structures of the inhibited cytoplasmic-open and matrix-open states support an alternating access mechanism, involving a …
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Probing the conformational changes of the yeast mitochondrial ADP/ATP carrier
The mitochondrial ADP/ATP carrier in the inner mitochondrial membrane imports ADP and exports ATP by switching between two conformational states. In the cytoplasmic state, which can be locked by carboxy-atractyloside, the substrate binding site is accessible to the cytoplasm, whereas in the matrix …
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Partial characterization of poly(ADP-ribosyl)ation in the brine shrimp Artemia.
Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1989.
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AZ OXIDATÍV STRESSZ ÉS POLI-ADP-RIBOZILÁCIÓ SZEREPÉNEK VIZSGÁLATA UVEÁLIS MELANOMA SEJTEKBEN
A PARP enzimek által katalizált poli-ADP-riboziláció, egy szerteágazó biológiai funkciójú poszttranszlációs fehérje módosítás. A PARP-1 fehérje DNS törések hatására aktiválódik, majd szubsztrátként a NAD+-ot használva, elágazó poli-ADP-ribóz (PAR) láncokat szintetizál akceptor proteinekhez és saját …
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A poli-ADP-riboziláció szerepe a HaCaT sejtek UVB sugárzás okozta sejthalálban
A poli-ADP-riboziláció szerepének vizsgálata HaCaT sejtvonalon UVB sugárzás hatására bekövetkező sejthalál során. Különböző PARP gátlószerek hatásának vizsgálata.
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