{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/92923"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/92923","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The chemical and enzymatic synthesis of poly(ADP-ribose)","abstract":"Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are methods for the synthesis of homogeneous poly(ADP-ribose) as well as the biology that is enabled by these synthetic efforts.","abstract_html":"Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are methods for the synthesis of homogeneous poly(ADP-ribose) as well as the biology that is enabled by these synthetic efforts.","abstract_has_math":false,"creators":["Lambrecht, Michael"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Hergenrother, Paul J.","Silverman, Scott K.","Mitchell, Douglas A.","Sarlah, David"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2016,"date_issued":"2016-11-10T18:27:41Z","date_published":"2016-11-10T18:27:41Z","updated_at":"2026-07-22T22:26:35Z","subjects":["Poly(ADP-ribose)","Total Synthesis","Enzymatic Synthesis","Poly(ADP-ribose) Polymerase","Poly ADP ribose polymerase (PARP)","Poly(ADP-ribose) Glycohydrolase (PARG)","Raptinal"],"languages":["en"],"rights":["Copyright 2016 Michael Lambrecht"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/92923","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hergenrother, Paul J.","Silverman, Scott K.","Mitchell, Douglas A.","Sarlah, David"]},{"key":"dc:creator","label":"Author","values":["Lambrecht, Michael"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2016-11-10T18:27:41Z","2018-11-11T10:15:12Z","2016-07-06","2016-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Poly(ADP-ribose)","Total Synthesis","Enzymatic Synthesis","Poly(ADP-ribose) Polymerase","Poly ADP ribose polymerase (PARP)","Poly(ADP-ribose) Glycohydrolase (PARG)","Raptinal"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2016 Michael Lambrecht"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/92923"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. 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