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University of Illinois at Urbana-Champaign
Fatty Acid and Biotin Metabolism in Escherichia Coli
Abstract
dc:descriptionBiotin which is essential for the synthesis of fatty acids in E. coli is thought to be derived from a modified fatty acid pathway. In experiments used to verify this hypothesis I discovered a new intermediate in biotin synthesis. This intermediate `X', was purified from the spent growth medium of strain sup151 (isolated as a bypass suppressor of a bioH mutation). Genetic data suggests that this intermediate is made by the action of the bioH and bioC gene products and its production is repressed by high levels of biotin in the growth medium via the BirA protein.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Microbiology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Subrahmanyam, Satyanarayana
- Contributors dc:contributor
-
- Cronan, John E., Jr
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI9912390
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/86739