Testosterone, Lycopene Isomers, and Prostate Cancer

The objective of the final study was to determine the influence of purified lycopene, tomato powder, and 20% diet restriction on N-methyl-N-nitrosourea (NMU)-testosterone-induced prostate cancer in rats. Survival was analyzed to include only rats that died with adenocarcinomas of the accessory sex glands. Only tomato powder-fed (RR = 0.570; P = 0.009) rats experienced significantly increased survival as compared to placebo beadlet-fed control rats. No significant influences of lycopene beadlet feeding or diet restriction as well as no interactions were noted for accessory sex gland-specific survival. We conclude that tomato powder may contain compounds, in addition to lycopene, which favorably modulate prostate carcinogenesis.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutritional Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Boileau, Thomas William-Maxwell

Contributors dc:contributor

• John W. Erdman, Jr.

• Health Sciences, Oncology

Language dc:language

eng

Identifier

(MiAaPQ)AAI9996618

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84992