Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability

Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P < 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutritional Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Boileau, Amy Christine

Contributors dc:contributor

• John W. Erdman, Jr.

• Health Sciences, Public Health

Language dc:language

eng

Identifier

(MiAaPQ)AAI9952968

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84984