{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84984"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84984","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability","abstract":"Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P < 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer.","abstract_html":"Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P &lt; 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer.","abstract_has_math":false,"creators":["Boileau, Amy Christine"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["John W. Erdman, Jr."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:31:12Z","date_published":"2015-09-25T22:31:12Z","updated_at":"2026-07-22T22:26:24Z","subjects":["Health Sciences, Public Health"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9952968"],"render_values":[{"text":"(MiAaPQ)AAI9952968","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84984","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["John W. Erdman, Jr."]},{"key":"dc:creator","label":"Author","values":["Boileau, Amy Christine"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:31:12Z","10000-01-01","1999"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Public Health"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84984","(MiAaPQ)AAI9952968"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P < 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer.","Made available in DSpace on 2015-09-25T22:31:12Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9952968.pdf: 7081266 bytes, checksum: 14c94b078b5313ff9fb896e38ea4fcb4 (MD5) Previous issue date: 1999","Embargo set by: Seth Robbins for item 86265 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","132 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999."]},{"key":"dc:title","label":"Title","values":["Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability"]}]}],"canonical_facts":{"dc:contributor":["John W. Erdman, Jr."],"dc:creator":["Boileau, Amy Christine"],"dc:date":["2015-09-25T22:31:12Z","10000-01-01","1999"],"dc:description":["Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P < 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer.","Made available in DSpace on 2015-09-25T22:31:12Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9952968.pdf: 7081266 bytes, checksum: 14c94b078b5313ff9fb896e38ea4fcb4 (MD5) Previous issue date: 1999","Embargo set by: Seth Robbins for item 86265 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","132 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999."],"dc:identifier":["http://hdl.handle.net/2142/84984","(MiAaPQ)AAI9952968"],"dc:language":["eng"],"dc:subject":["Health Sciences, Public Health"],"dc:title":["Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability"],"dc:type":["text"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:24Z"}