Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells

Conclusions. Interferon-γ, but not IFN-α, has a direct pathogenic role on the pancreatic β-cell. Early expression of IFN-α by the β-cell may contribute to insulitis whereas IFN-γ, a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\rm I\sb{A}$ in the prediabetic β-cell. Enhanced expression of the MHC class $\rm I\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in β-cells exposed to the insulitic cytokine IFN-γ..

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutritional Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Baldeon, Manuel Eduardo

Contributors dc:contributor

• Gaskins, H. Rex

• Biology, Animal Physiology

Language dc:language

eng

Identifier

(MiAaPQ)AAI9904386

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84978