Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 686 for “"interferon"”.
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Die Bedeutung von Interferon alpha und Interferon gamma auf den Verlauf der Marekschen Krankheit beim Haushuhn
… between host and virus needs to be expanded. Interferons are cytokines with antiviral activity. On the basis of their structural and functional features they can be divided into type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) interferons. Type I plays an important role during the early …
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Equine interferon-gamma and associated cytokines
… this effect we have initiated studies on equine interferon-gamma and related cytokines and obtained the following results. Equine interferon-gamma was cloned and produced in a variety of heterologous protein-expression systems. The biological activity of recombinant equine interferon-gamma was …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
… pathogens. The activated immune system produces interferon (IFNs), a cytokine that drives expression of antiviral effectors, known as IFN-stimulated genes (ISGs). The studies reported in this thesis investigate the differences in rotaviral infection of two human cell lines; the intestinal …
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Beta Cell Heterogeneity in the Acute Interferon Alpha Response
… system produces various cytokines, including interferon alpha (IFN-α), which has long been implicated in T1D pathogenesis. Our study explores how IFN-α influences human β-cell function, particularly its role in reactive oxygen species (ROS) production—signaling molecules essential for normal …
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Interferon-gamma hemmt die Replikation des Hepatitis-C-Virus
… C entwickeln, lieferten Hinweise darauf, dass Interferon(IFN)-gamma womöglich eine entscheidende Rolle dabei zukommt. Um eine antivirale Wirkung von IFN-gamma von einer immunmodulatorischen abzugrenzen, habe ich den Effekt von IFN-gamma auf die Protein- und RNA-Synthese von HCV mit Hilfe von …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
… is a major cause of liver disease. Only interferon-α (IFN-α) and the nucleosidic inhibitors of the viral polymerase, lamivudine and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and by the substantial resistance of the virus to …
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Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
Conclusions. Interferon-$\gamma,$ but not IFN-$\alpha,$ has a direct pathogenic role on the pancreatic $\beta$-cell. Early expression of IFN-$\alpha$ by the $\beta$-cell may contribute to insulitis whereas IFN-$\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic …
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Investigation of caveolae-mediated endocytosis in response to interferon
… a better understanding of the actions of type I interferons (IFN), cytokines that display potent antiviral as well as anti-cancer activity. IFN has a variety of cellular effects, some of which lead to its anti-tumor nature, but many of which are not fully understood. Some cellular effects may …
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The role of type I interferon in chronic lymphocytic leukemia
Type I interferon (IFN) has pleotropic and context-dependent biological effects. IFN's involvement in viral infections is well known but its precise role in cancer remains elusive. The aims of this thesis were to study the role of IFN in chronic lymphocytic leukemia (CLL), the most common adult …
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Identification and Characterization of Interferon-Stimulated Regulators of Bacterial Infection
The type I interferon activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes as a model bacterial pathogen, I sought to identify the roles of …
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LRBA Restricts Murine Colitis by Regulating Interferon Responses and Autophagy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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MECHANISM OF TRANSCRIPTIONAL REPRESSION OF MMP-9 BY INTERFERON-β
… Although it has been widely noted that interferon-beta; (IFN-beta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood. We describe here a novel …
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Cognitive, biological and psychosocial factors predicting interferon-alpha-induced depression
Interferon-alpha (IFN-α) therapy for chronic hepatitis C virus (HCV) infection is associated with the development of depression and other neuropsychiatric adverse effects. However, well-defined predictors of this depression are still lacking. Several interlinked biological systems as well as …
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Role of type I interferon in pulmonary inflammation and fibrosis
… Clinical studies have revealed elevated type I interferon (IFN-I) pathway activity in autoimmune patients with ILD compared to those without pulmonary involvement, with IFN-I levels positively correlating with disease severity, suggesting a potential pathogenic role in lung disease progression. …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… activity of immunomodulatory cytokines. </p><p>Interferons are a group of cytokines notable for their ability to shape immune responses. To some extent, this is accomplished through their ability to induce expression of families of GTPases. Herein, I describe my work characterizing the …
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Somatolactogenic hormones and interferon-gamma as regulators of neutrophil activation
… as well as the classic phagocyte activator, interferon-gamma (IFN-$\gamma$), in activating polymorphonulear neutrophils (PMN) from pigs, cows, rats and humans to kill Escherichia coli and secrete superoxide anion (O$\sb2\sp-$) after stimulation with phorbol myristate acetate (PMA). GH, as …
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CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
… duration and intensity of substrate signaling. Interferon-γ (IFN-γ), a critical antiviral cytokine, transduces its signal through the interferon-γ receptor (IFNGR), a single-pass heterodimeric receptor composed of IFNGR1 and IFNGR2. While the IFN-γ signal transduction pathway is well studied, …
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Interferon-γ aptamers for the diagnosis of extra-pulmonary tuberculosis
… challenging because of the low bacillary burden. Interferon gamma (IFN-γ) has been identified as a promising biomarker for the diagnosis of EPTB. The development of rapid and accurate point-of-care (POC) diagnostic technologies becomes crucial in controlling EPTB. Aptamers referred to as …
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