{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84978"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84978","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells","abstract":"Conclusions. Interferon-$\\gamma,$ but not IFN-$\\alpha,$ has a direct pathogenic role on the pancreatic $\\beta$-cell. Early expression of IFN-$\\alpha$ by the $\\beta$-cell may contribute to insulitis whereas IFN-$\\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\\rm I\\sb{A}$ in the prediabetic $\\beta$-cell. Enhanced expression of the MHC class $\\rm I\\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in $\\beta$-cells exposed to the insulitic cytokine IFN-$\\gamma.$.","abstract_html":"Conclusions. Interferon-<span class=\"etd-inline-math\">&gamma;,</span> but not IFN-<span class=\"etd-inline-math\">&alpha;,</span> has a direct pathogenic role on the pancreatic <span class=\"etd-inline-math\">&beta;</span>-cell. Early expression of IFN-<span class=\"etd-inline-math\">&alpha;</span> by the <span class=\"etd-inline-math\">&beta;</span>-cell may contribute to insulitis whereas IFN-<span class=\"etd-inline-math\">&gamma;,</span> a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\\rm I\\sb{A}$ in the prediabetic <span class=\"etd-inline-math\">&beta;</span>-cell. Enhanced expression of the MHC class $\\rm I\\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in <span class=\"etd-inline-math\">&beta;</span>-cells exposed to the insulitic cytokine IFN-<span class=\"etd-inline-math\">&gamma;.</span>.","abstract_has_math":true,"creators":["Baldeon, Manuel Eduardo"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Gaskins, H. Rex"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:31:11Z","date_published":"2015-09-25T22:31:11Z","updated_at":"2026-07-22T22:26:24Z","subjects":["Biology, Animal Physiology"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9904386"],"render_values":[{"text":"(MiAaPQ)AAI9904386","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84978","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gaskins, H. Rex"]},{"key":"dc:creator","label":"Author","values":["Baldeon, Manuel Eduardo"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:31:11Z","10000-01-01","1998"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Animal Physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84978","(MiAaPQ)AAI9904386"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Conclusions. Interferon-$\\gamma,$ but not IFN-$\\alpha,$ has a direct pathogenic role on the pancreatic $\\beta$-cell. Early expression of IFN-$\\alpha$ by the $\\beta$-cell may contribute to insulitis whereas IFN-$\\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\\rm I\\sb{A}$ in the prediabetic $\\beta$-cell. Enhanced expression of the MHC class $\\rm I\\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in $\\beta$-cells exposed to the insulitic cytokine IFN-$\\gamma.$.","Made available in DSpace on 2015-09-25T22:31:11Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9904386.pdf: 6003546 bytes, checksum: 03db5973040f1b50f05bcd7b44455598 (MD5) Previous issue date: 1998","Embargo set by: Seth Robbins for item 86259 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","128 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998."]},{"key":"dc:title","label":"Title","values":["Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells"]}]}],"canonical_facts":{"dc:contributor":["Gaskins, H. Rex"],"dc:creator":["Baldeon, Manuel Eduardo"],"dc:date":["2015-09-25T22:31:11Z","10000-01-01","1998"],"dc:description":["Conclusions. Interferon-$\\gamma,$ but not IFN-$\\alpha,$ has a direct pathogenic role on the pancreatic $\\beta$-cell. Early expression of IFN-$\\alpha$ by the $\\beta$-cell may contribute to insulitis whereas IFN-$\\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic decreases in glucose sensitivity and increased cell surface expression of MHC class $\\rm I\\sb{A}$ in the prediabetic $\\beta$-cell. Enhanced expression of the MHC class $\\rm I\\sb{A}$ antigen processing and presentation pathway and diminished insulin production appear to be distinct pathologic alterations in $\\beta$-cells exposed to the insulitic cytokine IFN-$\\gamma.$.","Made available in DSpace on 2015-09-25T22:31:11Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9904386.pdf: 6003546 bytes, checksum: 03db5973040f1b50f05bcd7b44455598 (MD5) Previous issue date: 1998","Embargo set by: Seth Robbins for item 86259 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","128 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1998."],"dc:identifier":["http://hdl.handle.net/2142/84978","(MiAaPQ)AAI9904386"],"dc:language":["eng"],"dc:subject":["Biology, Animal Physiology"],"dc:title":["Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells"],"dc:type":["text"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:24Z"}