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University of Illinois at Urbana-Champaign
Labeling of Proteins, Peptides, and Estrogens With Cyclopentadienyltricarbonylrhenium and Technetium
Abstract
dc:descriptionThe conjugation of cyclopentadienyltricarbonylrhenium to molecules having an affinity for the estrogen receptor is described. A variety of derivatives were prepared using either an indirect labeling or a preformed chelate approach, and of the compounds synthesized, ((17β-estradiol-17α-yl)-ethynylcyclopentadienyl) tricarbonylrhenium and its 11β-chloromethyl, ethyl and methoxy derivatives are attractive candidates for imaging estrogen receptors in vivo, having relative binding affinities (RBA's) for the estrogen receptor of 7.29%, 283%, 283% and 52.6%, respectively.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Spradau, Todd Walter
- Contributors dc:contributor
-
- Katzenellenbogen, John A.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI9904593
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84415