Labeling of Proteins, Peptides, and Estrogens With Cyclopentadienyltricarbonylrhenium and Technetium
type: CreativeWork
description: The conjugation of cyclopentadienyltricarbonylrhenium to molecules having an affinity for the estrogen receptor is described. A variety of derivatives were prepared using either an indirect labeling or a preformed chelate approach, and of the compounds synthesized, ((17$\beta$-estradiol-17$\alpha$-yl)-ethynylcyclopentadienyl) tricarbonylrhenium and its 11$\beta$-chloromethyl, ethyl and methoxy derivatives are attractive candidates for imaging estrogen receptors in vivo, having relative binding affinities (RBA's) for the estrogen receptor of 7.29%, 283%, 283% and 52.6%, respectively.
abstract: The conjugation of cyclopentadienyltricarbonylrhenium to molecules having an affinity for the estrogen receptor is described. A variety of derivatives were prepared using either an indirect labeling or a preformed chelate approach, and of the compounds synthesized, ((17$\beta$-estradiol-17$\alpha$-yl)-ethynylcyclopentadienyl) tricarbonylrhenium and its 11$\beta$-chloromethyl, ethyl and methoxy derivatives are attractive candidates for imaging estrogen receptors in vivo, having relative binding affinities (RBA's) for the estrogen receptor of 7.29%, 283%, 283% and 52.6%, respectively.
author: Spradau, Todd Walter
language: eng
keywords: Chemistry, Inorganic
date published: 2015-09-25T22:14:22Z
date modified: 2026-07-22T22:26:23Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/84415