University of Illinois at Urbana-Champaign
Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection
Abstract
dc:descriptionA variety of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the sensory neurons of the sensorimotor synapse and induces a larger cellular response on the motor neurons than L-Asp. A method for single cell analysis of D-amino acid containing peptides in Aplysia abdominal neurons has been developed and the D-form dominates in one diastereomer pair. Lastly, in preliminary studies, the release of L-Glu versus acetylcholine from specific regions of the brain of freely moving rats appears dependent on stimulation parameters, causing differential regulation of the circadian systems.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Miao, Hai
- Contributors dc:contributor
-
- Sweedler, Jonathan V.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3182442
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84179