{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84179"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84179","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection","abstract":"A variety of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the sensory neurons of the sensorimotor synapse and induces a larger cellular response on the motor neurons than L-Asp. A method for single cell analysis of D-amino acid containing peptides in Aplysia abdominal neurons has been developed and the D-form dominates in one diastereomer pair. Lastly, in preliminary studies, the release of L-Glu versus acetylcholine from specific regions of the brain of freely moving rats appears dependent on stimulation parameters, causing differential regulation of the circadian systems.","abstract_html":"A variety of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the sensory neurons of the sensorimotor synapse and induces a larger cellular response on the motor neurons than L-Asp. A method for single cell analysis of D-amino acid containing peptides in Aplysia abdominal neurons has been developed and the D-form dominates in one diastereomer pair. Lastly, in preliminary studies, the release of L-Glu versus acetylcholine from specific regions of the brain of freely moving rats appears dependent on stimulation parameters, causing differential regulation of the circadian systems.","abstract_has_math":false,"creators":["Miao, Hai"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Sweedler, Jonathan V."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:13:21Z","date_published":"2015-09-25T22:13:21Z","updated_at":"2026-07-22T22:26:22Z","subjects":["Biology, Neuroscience"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3182442"],"render_values":[{"text":"(MiAaPQ)AAI3182442","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84179","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Sweedler, Jonathan V."]},{"key":"dc:creator","label":"Author","values":["Miao, Hai"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:13:21Z","10000-01-01","2005"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Neuroscience"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84179","(MiAaPQ)AAI3182442"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A variety of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. 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Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the sensory neurons of the sensorimotor synapse and induces a larger cellular response on the motor neurons than L-Asp. A method for single cell analysis of D-amino acid containing peptides in Aplysia abdominal neurons has been developed and the D-form dominates in one diastereomer pair. Lastly, in preliminary studies, the release of L-Glu versus acetylcholine from specific regions of the brain of freely moving rats appears dependent on stimulation parameters, causing differential regulation of the circadian systems.","Made available in DSpace on 2015-09-25T22:13:21Z (GMT). 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