Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2

Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the amounts of both pre-β HDL and α-HDL. In contrast, inhibition of PLTP activity in the cell medium by anti-PLTP IgG resulted in a decrease in the secreted HDL fraction having a hydrated density of 1.10 g/ml. This reduction was also associated with decreases in the amounts of pre-β HDL and α-HDL.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Food Science and Human Nutrition

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Guo, Ziwen

Contributors dc:contributor

• Nishida, Toshiro

• Chemistry, Biochemistry

Language dc:language

eng

Identifier

(MiAaPQ)AAI9812606

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/83722