{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/83722"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/83722","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2","abstract":"Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the amounts of both pre-$\\beta$ HDL and $\\alpha$-HDL. In contrast, inhibition of PLTP activity in the cell medium by anti-PLTP IgG resulted in a decrease in the secreted HDL fraction having a hydrated density of 1.10 g/ml. This reduction was also associated with decreases in the amounts of pre-$\\beta$ HDL and $\\alpha$-HDL.","abstract_html":"Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the amounts of both pre-<span class=\"etd-inline-math\">&beta;</span> HDL and <span class=\"etd-inline-math\">&alpha;</span>-HDL. In contrast, inhibition of PLTP activity in the cell medium by anti-PLTP IgG resulted in a decrease in the secreted HDL fraction having a hydrated density of 1.10 g/ml. This reduction was also associated with decreases in the amounts of pre-<span class=\"etd-inline-math\">&beta;</span> HDL and <span class=\"etd-inline-math\">&alpha;</span>-HDL.","abstract_has_math":true,"creators":["Guo, Ziwen"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Food Science and Human Nutrition","degree_department":null,"school":null,"contributors":["Nishida, Toshiro"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T21:10:12Z","date_published":"2015-09-25T21:10:12Z","updated_at":"2026-07-22T22:26:21Z","subjects":["Chemistry, Biochemistry"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9812606"],"render_values":[{"text":"(MiAaPQ)AAI9812606","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/83722","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Nishida, Toshiro"]},{"key":"dc:creator","label":"Author","values":["Guo, Ziwen"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T21:10:12Z","10000-01-01","1997"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Food Science and Human Nutrition"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Biochemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/83722","(MiAaPQ)AAI9812606"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the amounts of both pre-$\\beta$ HDL and $\\alpha$-HDL. In contrast, inhibition of PLTP activity in the cell medium by anti-PLTP IgG resulted in a decrease in the secreted HDL fraction having a hydrated density of 1.10 g/ml. This reduction was also associated with decreases in the amounts of pre-$\\beta$ HDL and $\\alpha$-HDL.","Made available in DSpace on 2015-09-25T21:10:12Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9812606.pdf: 5802905 bytes, checksum: ea7a2d3df2b2588923bb3fcf9127491b (MD5) Previous issue date: 1997","Embargo set by: Seth Robbins for item 85003 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","107 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997."]},{"key":"dc:title","label":"Title","values":["Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2"]}]}],"canonical_facts":{"dc:contributor":["Nishida, Toshiro"],"dc:creator":["Guo, Ziwen"],"dc:date":["2015-09-25T21:10:12Z","10000-01-01","1997"],"dc:description":["Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the amounts of both pre-$\\beta$ HDL and $\\alpha$-HDL. In contrast, inhibition of PLTP activity in the cell medium by anti-PLTP IgG resulted in a decrease in the secreted HDL fraction having a hydrated density of 1.10 g/ml. This reduction was also associated with decreases in the amounts of pre-$\\beta$ HDL and $\\alpha$-HDL.","Made available in DSpace on 2015-09-25T21:10:12Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9812606.pdf: 5802905 bytes, checksum: ea7a2d3df2b2588923bb3fcf9127491b (MD5) Previous issue date: 1997","Embargo set by: Seth Robbins for item 85003 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","107 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997."],"dc:identifier":["http://hdl.handle.net/2142/83722","(MiAaPQ)AAI9812606"],"dc:language":["eng"],"dc:subject":["Chemistry, Biochemistry"],"dc:title":["Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2"],"dc:type":["text"],"thesis:degree_discipline":["Food Science and Human Nutrition"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:21Z"}