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University of Illinois at Urbana-Champaign
Engineering of Nonviral Vectors for Gene Therapy
Abstract
dc:descriptionFinally, for polymeric devices to be made safe and efficient for in vivo usage there must be some means to target them to specific cells or tissues. Various cyclodextrins were conjugated to PEI using an amide linkage. The hydrophobic interior of the cyclodextrin allows the facile addition of small targeting and lysomotropic agents to the polyplex without chemical conjugation. By applying a hydrophobic analog of human insulin to the cyclodextrin polyplexes, I was able demonstrate a 2--3 fold enhancement in transfection efficiency in insulin receptor-rich cell lines.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemical and Biomolecular Engineering
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Forrest, Marcus Laird
- Contributors dc:contributor
-
- Pack, Daniel W.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3101840
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/82352