Study of phenotypic and gene expression response to bacterial challenge

In the mouse model of Bacillus Calmette-Guérin (BCG)-induced inflammation, focus is placed upon phenotypic and gene-expression responses to the original challenge. Studies of the phenotypic response to BCG involves several behavior indicators, categorized as representing an initial period of sickness response, and a set of depression-like behaviors that can endure for several weeks. Little is known about the impact of relationships among indicators on these studies, as most analyses have treated indicators independently. Gene-expression studies have also been small in scale, limiting what is known about gene-expression during these behavioral changes. With the availability of Next-Generation Sequencing platforms, the scale of transcriptome analysis can be greatly increased. This study aims to address these previous limitations, characterizing behavioral and gene-expression responses to BCG-induced inflammation.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Informatics

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Nixon, Scott Evan

Contributors dc:contributor

• Rodriguez-Zas, Sandra L.
• Caetano-Anollés, Gustavo
• Chen, Xiaohui
• Kelley, Keith W.

• Behavior
• Transcriptome
• Functional Analysis

Statement dc:rights

• Copyright 2015 Scott Nixon

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/78763

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/78763