Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 899 for “"Transcriptome"”.
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Defining the human endothelial transcriptome
Advances in microarray technology facilitate the study of biological systems at a genome-wide level. Meaningful analysis of these transcriptional profiling studies, however, demands the concomitant development of novel computational techniques that take into account the size and complexity of the …
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Mining the Medulloblastoma Genome and Transcriptome
… of the central nervous system. Recently, transcriptome-wide profiling has dissected medulloblastoma from one single disease into four disparate molecular subgroups – namely WNT, SHH, Group3 and Group4. Distinct genomic, cytogenetic, mutational and clinical spectra associated with these …
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Transcriptome Analysis of Sea Lamprey Embryogenesis
… in the Eye Spot/Melanophore comparisons. This transcriptome analysis serves as a starting point for determining vital genes in sea lamprey embryogenesis and controlling the sea lamprey population.</p>
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Exploration of the mouse osteoblast transcriptome
Contains fulltext : 30023.pdf (Publisher’s version ) (Open Access)
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Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis
… this doctoral dissertation examines the transcriptome of all three subfields, DG, CA3, and CA1 in human postmortem tissue of controls and individuals diagnosed with schizophrenia, using RNA-seq to identify additional psychosis-mediating molecular candidates and produce plausible targets …
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Contextual Insights into the Rett Syndrome Transcriptome
… RTT-associated mutation types. By assessing RTT transcriptomes across various neuronal contexts, I propose a novel contextualized paradigm for MeCP2 function in neuronal cell types that not only hypothesizes how MeCP2 dysfunction leads to the cellular deficits that give rise to RTT-like …
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The developmental liver transcriptome of Rattus norvegicus
Our research is involved in the transcriptional dynamics of perinatal liver development. The transcription factors and their downstream effects have been well studied in regards to early liver development, yet perinatal liver development is much less well understood. In an attempt to investigate …
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Integrative analysis of the metastatic neuroblastoma transcriptome
… biology of high-risk NBLs, I investigated whole transcriptome profiles of two cohorts of metastatic NBLs using RNA sequencing. First, I studied changes in splicing pattern in a cohort of 29 patients. V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog (MYCN) amplified NBLs …
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Spatial Transcriptome Profiling of Gastrulating Primate Embryos
… allowed me to then perform spatially defined transcriptome profiling. Preserving the spatial coordinates of each sample processed for transcriptome analysis enabled me to integrate the transcriptome information of each sample individually into 3D embryo reconstructions. A collaborator applied …
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Mapping the Spatial Transcriptome Across Whole Organisms
… (ExSeq) to thoroughly investigate the spatial transcriptome of the Caenorhabditis elegans (C. elegans) body. Beyond mapping gene distribution within individual specimens, this research sequences multiple C. elegans to identify both shared and distinct transcriptomic features. The findings lay …
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Carbon Starvation Metabolically Regulates Chromatin for Transcriptome Rewiring
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Validating ngn-1 transcriptome targets in C. elegans
<p>A detailed understanding of how the central nervous system (CNS) is formed and connects during early development can provide information on how to understand and treat disease progression associated with CNS dysregulation. Neurodevelopmental disorders are often reported to be polygenetic in …
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Novel methods in transcriptome analysis using RNA-seq
RNA-seq has proven to be a powerful technique for transcriptome profiling based on next-generation sequencing (NGS) technologies. Using RNA-seq, we want to solve two critical challenges: identifying Splice Junctions (SJs) and annotating gene fusion transcripts. Due to the limited read length of NGS …
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Assembly and analysis of the miscanthus × giganteus transcriptome
Made available in DSpace on 2011-05-25T14:27:55Z (GMT). No. of bitstreams: 2 Barling_Adam.pdf: 1699625 bytes, checksum: cedaa82b35a48883047793b6062fb184 (MD5) license.txt: 4061 bytes, checksum: 61fe40f251d63ab03773551d76de0942 (MD5)
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Shaping the bacterial transcriptome: Perspectives from kinetic modeling
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Olfactory Ensheathing Cell Development: A Transcriptome Profiling Approach
… Schwann cell differentiation, I took an unbiased transcriptome profiling approach. Taking advantage of Sox10 expression throughout both OEC and Schwann cell development, I used laser-capture microdissection on cryosections of mouse embryos carrying a Sox10:H2BVenus transgene, to isolate OEC …
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The Drosophila Interactions Database: Integrating The Interactome And Transcriptome
<p>In this thesis I describe the integration of heterogeneous interaction data for <i>Drosophila</i> into DroID, the <i>Drosophila</i>interactions database, making it a one-stop public resource for interaction data. I have also made it possible to filter the interaction data using gene expression …
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Cell Type-specific Analysis of Human Interactome and Transcriptome
Cells are the fundamental building block of complex tissues in higher-order organisms. These cells take different forms and shapes to perform a broad range of functions. What makes a cell uniquely eligible to perform a task, however, is not well-understood; neither is the defining characteristic …
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RNA and DNA Sequence Analysis of the Human Transcriptome
… of DNA into RNA. As such, the study of the transcriptome, or the characterization and quantification of all RNA produced in the cell, is important. Recent advances in sequencing technology have allowed for unprecedented interrogation of the transcriptome at single-nucleotide resolution. In …
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