A Pathobiochemical Investigation of Glucocorticoid Hepatopathy and Alkaline Phosphatase Isozymes in the Dog

Glucocorticoids administered to dogs produce hepatic histologic changes, characterized by hepatocellular swelling and vacuolization (glucocorticoid hepatopathy), and dramatic serum increases of liver alkaline phosphatase (LALP) and a novel isozyme, corticosteroid alkaline phosphatase (CALP). Using liver biopsy, morphometric techniques and quantitative biochemical and immunochemical analyses to investigate the role of CALP in glucocorticoid hepatopathy, I have determined the early kinetics of: (1) appearance and degree of in vivo hepatocellular swelling, (2) hepatic glycogen accumulation and (3) increases of LALP and CALP in both serum and liver.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Medical Science

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Rippy, Marian Kathleen

Contributors dc:contributor

• Kuhlenschmidt, Mark S.

• Agriculture, Animal Pathology
• Chemistry, Biochemistry

Identifier

(UMI)AAI8908813

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/71355