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Showing 1 to 18 of 18 for “"Liver biopsy"”.
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A Comparison of Liver Biopsy Techniques in Dogs
Background: The liver biopsy technique in dogs that consistently provides samples adequate for accurate histopathologic interpretation and the variability of histopathology among lobes is unknown. Hypothesis: Liver biopsy specimens obtained via punch, cup biopsy, and 14 gauge needle biopsy would …
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The liver in disease: with special reference to aspiration liver biopsy
… biochemical methods used in the study of liver diseases with the histological appearance of the liver. The liver in acute hepatitis and obstructive jaundice is described in some detail, and next come reports of various cases in which the method has been applied either diagnostically or for …
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Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period
Background: Liver biopsy is a fundamental diagnostic tool in clinical hepatology, also playing a crucial role in the prognostication and management of liver diseases. Previous studies at various centres have examined liver biopsies in the context of liver disease workups, including indications, …
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Prediction of Compensated Liver Cirrhosis by Ultrasonography and Routine Blood Tests in Patients with Chronic Viral Hepatitis
BACKGROUND: A liver biopsy is the standard method for the diagnosis of liver cirrhosis in patients with chronic hepatitis. Because the liver biopsy is an invasive method, non-invasive methods have been used to diagnose compensated liver cirrhosis in patients with chronic hepatitis. The current …
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Evaluation of serum prolidase activity as a marker for liver fibrosis in suspected liver disease
Liver dysfunction is common, often unrecognised and likely to increase in incidence in the population in parallel with the obesity and attendant type 2 diabetes mellitus epidemics. Liver fibrosis is a significant finding in liver pathology as it imparts important clinical staging and prognostic …
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Platelet Function in Dogs with Chronic Liver Disease
Background: Dogs with acquired chronic liver disease often have hemostatic derangements. It is currently unknown whether dogs with acquired chronic liver disease have decreased platelet function and alterations in von Willebrand factor (vWF) that may contribute to hemostatic abnormalities. …
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A Pathobiochemical Investigation of Glucocorticoid Hepatopathy and Alkaline Phosphatase Isozymes in the Dog
… hepatopathy), and dramatic serum increases of liver alkaline phosphatase (LALP) and a novel isozyme, corticosteroid alkaline phosphatase (CALP). Using liver biopsy, morphometric techniques and quantitative biochemical and immunochemical analyses to investigate the role of CALP in glucocorticoid …
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Caspase-cleaved fragments of cytokeratin-18 as a marker of inflammatory activity in chronic hepatitis B virus infection
… A total of 339 CHB patients who underwent liver biopsy, were included. Serum M30 antigen levels were compared with inactive carriers (n=36), patients with HBeAg- negative hepatitis (n=80), HBeAg-positive hepatitis (n=141) and liver cirrhosis (n=82). RESULTS: Serum M30 antigen levels were …
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Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение
… of modern methods for comprehensive diagnosis of liver fibrosis and the results of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of …
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The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis
… the role of the UPR in the progression of liver disease is not well understood, we established an in vitro model to evaluate the role of the UPR in NASH and translated results to clarify disease progression in human liver biopsy samples. Treating HepG2 cells and primary human hepatocytes …
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NON-INVASIVE METHODS TO PREDICT AND MONITORING METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE BY USING ULTRASOUND IMAGING
Metabolic-Associated Steatotic Liver Disease (MASLD) is becoming increasingly critical due to its rising global prevalence and its potential to progress to more severe liver diseases, such as Metabolic-Associated Steatohepatitis (MASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The …
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Orthotopic liver transplantation at Groote Schuur Hospital : a serial analysis of biliary cytokines and biochemical parameters
Orthotopic liver transplantation is the treatment of choice for many patients with end-stage liver disease. Despite advances in immunosuppression, acute rejection remains common (up to 70%) and results in significant patient morbidity. It is frequently difficult to distinguish abnormal liver …
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Clinical Parameters Are More Predictive of Mortality in Alcoholic Hepatitis than Histopathologic Severity
… aids definitive diagnosis, the role of the liver biopsy in its workup is still controversial. Currently, there is no widely accepted grading histologic grading system for AH. The relationship between biopsy findings and clinical course is also yet unknown. The Alcoholic Hepatitis Histologic …
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Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell and Gene Therapy
… of cancer stem-like cells (CSCs) traits in liver derived cell lines. These traits include enhanced expression of putative stem cell markers DCAMKL-1, Lgr5, CD133 and c-Myc. We also showed that HCV replication is severely impaired by siRNA-led depletion of the microtubule filaments …
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Bioinformatics e Biostatistics applied to research in pediatric genetic disease. Clinical evidence in IFNλ4 polymorphisms associated with HCV infection in patients with beta thalassemia and WGCNA analysis weighted for IFNλ4 genotype rs12979860 to detect RPL9P18 as hub in HCV infected cell.
… and fibrosis stage directly shown by the liver biopsy was found. Second part of our study was to identify hub genes associated in pathways closely related to IFNλ4 variants in HCV response. We used gene expression profile data of GSE54648, downloaded from Gene Expression Omnibus (GEO). We …
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T-lymphocyte senescence and hepatitis C virus infection
… non-viraemic HCV had short CD8+ telomere length. Liver biopsy tissue from a cohort of subjects with non-viraemic HCV was studied and demonstrated significant inflammation or fibrosis in most. To study the IFN-α signalling pathway in cells with short telomeres, I utilised the phospho-histone …
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The Budd-Chiari syndrome : a study of diagnosis, haemodynamics and treatment
… and haemodynamic features. The diagnosis of liver disease has been revolutionized by such special techniques as percutaneous liver biopsy, portal pressure measurements, isotope scanning and selective arteriography and venography. This study describes six patients with the Budd-Chiari syndrome …