A Pathobiochemical Investigation of Glucocorticoid Hepatopathy and Alkaline Phosphatase Isozymes in the Dog
Glucocorticoids administered to dogs produce hepatic histologic changes, characterized by hepatocellular swelling and vacuolization (glucocorticoid hepatopathy), and dramatic serum increases of liver alkaline phosphatase (LALP) and a novel isozyme, corticosteroid alkaline phosphatase (CALP). Using liver biopsy, morphometric techniques and quantitative biochemical and immunochemical analyses to investigate the role of CALP in glucocorticoid hepatopathy, I have determined the early kinetics of: (1) appearance and degree of in vivo hepatocellular swelling, (2) hepatic glycogen accumulation and (3) increases of LALP and CALP in both serum and liver.
Agriculture, Animal Pathology, Chemistry, Biochemistry
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign