A Pathobiochemical Investigation of Glucocorticoid Hepatopathy and Alkaline Phosphatase Isozymes in the Dog
type: CreativeWork
description: Glucocorticoids administered to dogs produce hepatic histologic changes, characterized by hepatocellular swelling and vacuolization (glucocorticoid hepatopathy), and dramatic serum increases of liver alkaline phosphatase (LALP) and a novel isozyme, corticosteroid alkaline phosphatase (CALP). Using liver biopsy, morphometric techniques and quantitative biochemical and immunochemical analyses to investigate the role of CALP in glucocorticoid hepatopathy, I have determined the early kinetics of: (1) appearance and degree of in vivo hepatocellular swelling, (2) hepatic glycogen accumulation and (3) increases of LALP and CALP in both serum and liver.
abstract: Glucocorticoids administered to dogs produce hepatic histologic changes, characterized by hepatocellular swelling and vacuolization (glucocorticoid hepatopathy), and dramatic serum increases of liver alkaline phosphatase (LALP) and a novel isozyme, corticosteroid alkaline phosphatase (CALP). Using liver biopsy, morphometric techniques and quantitative biochemical and immunochemical analyses to investigate the role of CALP in glucocorticoid hepatopathy, I have determined the early kinetics of: (1) appearance and degree of in vivo hepatocellular swelling, (2) hepatic glycogen accumulation and (3) increases of LALP and CALP in both serum and liver.
author: Rippy, Marian Kathleen
keywords: Agriculture, Animal Pathology, Chemistry, Biochemistry
date published: 2014-12-16T06:35:54Z
date modified: 2026-07-22T22:26:04Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/71355