Advances in Fast Atom Bombardment Mass-Spectrometry (Glycosphingolipids, Nucleotides, Markers, Negative Ion)

The capabilities and limitations of the recently introduced technique of fast atom bombardment mass spectrometry were explored. A comparison of fast atom bombardment and field desorption mass spectrometry was made to determine relative sensitivity and applicability. A series of glycosphingolipids and a series of protected oligonucleotides of known structure were analyzed to ascertain the potential utility of fast atom bombardment mass spectrometry in the structural elucidation of novel compounds in these classes. Negative ion mass markers, necessary for accurate mass measurements of the aforementioned classes of compounds and in newly proposed scanning accurate mass measurement methods, were also developed.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Hemling, Mark Elliott

• Chemistry, Analytical

Identifier

(UMI)AAI8623317

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/70326