Advances in Fast Atom Bombardment Mass-Spectrometry (Glycosphingolipids, Nucleotides, Markers, Negative Ion)
The capabilities and limitations of the recently introduced technique of fast atom bombardment mass spectrometry were explored. A comparison of fast atom bombardment and field desorption mass spectrometry was made to determine relative sensitivity and applicability. A series of glycosphingolipids and a series of protected oligonucleotides of known structure were analyzed to ascertain the potential utility of fast atom bombardment mass spectrometry in the structural elucidation of novel compounds in these classes. Negative ion mass markers, necessary for accurate mass measurements of the aforementioned classes of compounds and in newly proposed scanning accurate mass measurement methods, were also developed.
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign