Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Structural Elucidation"”.
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Structural Elucidation of [RNQ+] prions Transmissible Infectivity
… is observed within yeast also. To decipher how structural differences between infectious and non-infectious amyloid form, we formulated the hypothesis that structural differences in Rnq1 prion formation account for drastic changes within the amyloid. Here I show that different strains of [RNQ+] …
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Isolation and Structural Elucidation of Compounds from Natural Products
… studied to identify their chemical components. Structural elucidation and characterization of the compounds were done using mass spectrometry, 1D and 2D NMR spectroscopy techniques. A systematic study of the ethanol extract of the plant Neoharmsia baronii Drake from the Madagascar forest led to …
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Design, synthesis, and structural elucidation of spiroligomers for targeted molecular recognition
… spiroligomer anion receptors, this work advances structural validation by obtaining crystall structures for all stereoisomeric receptors and a high-affinity phosphate-bound complex. Together with previously acquired NMR titration data, these structures reveal a strong stereochemical preference for …
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Structural elucidation of glycerophospholipids using metastable atom-activated dissociation mass spectrometry (MAD-MS)
Recent developments in analytical instrumentation have allowed scientists to investigate systems that were unattainable in the past. In the biomedical community this increase in investigative power has allowed the exploration of biological components like proteins, lipids, and DNA and their role in …
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The application of nuclear magnetic resonance in the structural elucidation of natural products
… Resonance (NMR) techniques were investigated via structural assignment of various natural products. The natural products chosen for investigation of 2D NMR spectroscopy as a structural tool were the opium alkaloids codeine and papaverine, the diterpenoid alkaloids delphinine and aconitine and the …
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Structural Elucidation of the Interaction Between Neurodegenerative Disease-Related Tau Protein with Model Lipid Membranes
… with model lipid membranes to elucidate the structural perturbations those interactions induced in tau protein and in the membrane. We show that although tau is highly charged and soluble, it is highly surface active and preferentially interacts with anionic membranes. To resolve …
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Towards the Structural Elucidation and Total Synthesis of Hemicalide: Assignment of the C29-C46 Region
… cases, low isolation yields and lack of full structural information necessitate total synthesis to achieve their structural elucidation, and produce sufficient material for biological studies. This thesis outlines the synthesis and stereochemical assignment of the C29-C46 region of hemicalide …
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Structural elucidation of a common architecture of the nuclear pore complex and COPIl vesicle coats
… and a myriad of other cellular processes. Elucidation of the structure of the NPC is thus expected to provide important insight into cell biology. In this thesis, I investigate the structure of a key subcomplex of the NPC and discuss the evolutionary relationship between the NPC and COPIl …
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STRUCTURAL ELUCIDATION OF DEPROTONATED ANALYTES VIA TANDEM MASS SPECTROMETRY BASED ON ION-MOLECULE REACTIONS AND COLLISION-ACTIVATED DISSOCIATION
… m/z value of the ionized analyte. In addition, structural information can be obtained via tandem mass spectrometry methods such as collision-activated dissociation (CAD). However, CAD does not always guarantee unambiguously assignment of chemical structures, therefore, additional tandem mass …
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The Design And Synthesis Of Inhibitors Of Hiv-1 Viral Entry And Photoaffinity Labeled Probes For Structural Elucidation Of The Hiv-1 Env
… literature. This work is expected to enable both structural elucidation of this critical Env conformation and aid the development of an HIV-1 vaccine.
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Mass Spectrometric Studies on Lignin Sequencing and Fast Pyrolysis, Functional-Group Selective Ion-Molecule Reactions and Reactivity of Bi- and Triradicals
… be an invaluable tool for mixture analysis and structural elucidation of mixture components. Tandem mass spectrometry (MS/MS) utilizing collision-activated dissociation (CAD) has become the technique of choice for structural elucidation of unknown analytes. The coupling of MS/MS with high …
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Structural analysis of capsular polysaccharides produced by some emerging Klebsiella pneumoniae serotypes
… This project involved the characterisation and structural elucidation of the CPS repeating unit (RU) structures, known as chemotyping, of four emerging clinically significant strains of K. pneumoniae, which were identified through genotyping as novel serotypes: KL102; KL112; KL122; and KL107. …
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Advances in Fast Atom Bombardment Mass-Spectrometry (Glycosphingolipids, Nucleotides, Markers, Negative Ion)
… fast atom bombardment mass spectrometry in the structural elucidation of novel compounds in these classes. Negative ion mass markers, necessary for accurate mass measurements of the aforementioned classes of compounds and in newly proposed scanning accurate mass measurement methods, were also …
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Therapeutics discovery via glycotechnology : the development of protein engineered enzymes for the study of galactosaminoglycan neuromedicine
… agents, these molecules are characterized by a structural complexity that has thus far prevented their widespread exploitation in biomedicine. Insight into the fine structure and sequence of these complex biomolecules provides a novel niche for the development of therapeutic interventions. Such …
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An electrochemical pipette for the study of drug metabolite
… structure of the TLE facilitate comprehensive structural elucidation of intermediates and products using chromatographic and spectroscopic techniques.
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Stress and release : chemical modulation of secondary metabolite production in Aspergillus sp.
… were the aspulvinones, a class of butenolides. Structural elucidation of four isolated aspulvinones revealed both known and novel structures. Inducer concentration had a significant impact on aspulvinone profile. Bioassay revealed previously unreported antibacterial activity for the …
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Mass Spectrometric Studies on the Primary Products of Fast Pyrolysis of Carbohydrates and the Molecular Structures of Asphaltenes, and the Development of a Rastering Probe for Laser-Induced Acoustic Desorption into an Atmospheric Pressure Chemical Ionization Source
… invaluable in the field of mixture analysis and structural elucidation. Tandem mass spectrometry (MS/MS) utilizing collision-activated dissociation (CAD) has become the technique of choice for structural elucidation of unknown analytes in mixtures. When coupled with gas chromatography (GC) or …
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Isolation, Synthesis and Structure-Activity Relationship Study of Anticancer and Antimalarial Agents from Natural Products
… and optical rotation data. Other than structural elucidation, this work also involved bioactivity evaluations of all the isolates, as well as total synthesis of the two antiproliferative sesquiterpenoids, and a structure-activity relationship (SAR) studies on the antiplasmodial …
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