Cellular Immunity in Hamsters After Immunization With Vaccinia Virus: Studies on Macrophage Functional Heterogeneity and Interactions Between Natural Killer Cells and Macrophages

This study demonstrated that macrophage (M(phi)) subpopulations can be isolated from normal and vaccinia virus-immune peritoneal exudate cells after separation on bovine serum albumin (BSA) discontinuous density gradients. The M(phi) subpopulations from normal and early- or late-immune animals were all phagocytic but differed in their ability to mediate cytotoxicity. Normal M(phi) subpopulations were not cytotoxic, whereas the 40/30 and pellet fractions collected from BSA gradients of immune M(phi)s were cytotoxic. In contrast, M(phi)s isolated from the lighter fractions were found to be poor killer cells.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Medical Science

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Chapes, Stephen Keith

• Health Sciences, Immunology

Language dc:language

eng

Identifier

(UMI)AAI8114398

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/68235