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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Cellular immunity"”.
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Cellular Immunity to Fowlpox Virus in Chickens
Made available in DSpace on 2014-12-11T21:33:49Z (GMT). No. of bitstreams: 1 7414595.pdf: 4076738 bytes, checksum: f4538ebe86aa0aa8ffe4a34d6329d255 (MD5) Previous issue date: 1974
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Cellular Immunity in Mouse Models of Viral Encephalitis
… the intranasal route and then characterized the cellular elements that infiltrate the brain as well as the activation status of resident microglia, cells widely believed to represent the major APC population in the CNS. To exclude a contribution of peripheral dendritic cells (DCs), a population …
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Cellular immunity of naïve and BCG vaccinated neonates
… cytokine profile in the newborn child, whereas immunity to Mycobacterium tuberculosis (Mtb) is associated with the development of a type 1 helper (Th1) cytokine response, could impact on the subsequent adaptive immune response to BCG vaccination. Previous studies have suggested that immune …
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Delayed-type hypersensitivity and cellular immunity to Leishmania donovani
Thesis (M.S.)--Michigan State University. Dept. of Microbiology and Public Health, 1970
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Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy
… both phenotypic and functional T and B cell immunity. HIV-infected women were studied before and 1 year after ART initiation. In Chapter 2, the effect of ART on T cell activation and differentiation profiles was evaluated in HIV-infected individuals (n=28; pre- and post-ART), and compared to …
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Forced-Exercise Dependent Changes in Cellular Immunity: Effects on Experimental Autoimmune Neuritis
<p>Guillain-Barré Syndrome (GBS) is a debilitating inflammatory autoimmune disease of the peripheral nervous system that is characterized by rapid-onset paraparesis with areflexia progressing to neuromuscular paralysis. The most common form of GBS observed in North America and Europe is acute …
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Deciphering Features of Protective or Maladaptive Cellular Immunity in the Airways Following Primary and Repeated Pathogen Exposure
… from homeostatic conditions. The airway’s cellular constituents – epithelial, stromal, and immune cells – maintain local and global homeostasis by facilitating gas exchange and providing a barrier against noxious environmental agents (e.g., xenobiotics, allergens, toxins, and microbes). …
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Cellular Immunity in Hamsters After Immunization With Vaccinia Virus: Studies on Macrophage Functional Heterogeneity and Interactions Between Natural Killer Cells and Macrophages
This study demonstrated that macrophage (M(phi)) subpopulations can be isolated from normal and vaccinia virus-immune peritoneal exudate cells after separation on bovine serum albumin (BSA) discontinuous density gradients. The M(phi) subpopulations from normal and early- or late-immune animals were …
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Identification of protective rickettsial antigens for vaccine development
… to rickettsial infections and cross-protective immunity between typhus and spotted fever group rickettsiae are attributed to the induction of antigen-specific T cells, particularly CD8+ T cells. Defining specific T-cell antigens and correlates of protective cellular immunity are critical steps …
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Toxin-like proteins in the venom of Drosophila parasitoids
… Drosophila yakuba, a host species with a strong cellular immunity, and infected flies are unable to mount a strong immune response. To predict possible toxin-like proteins in Ganaspis venoms that might suppress cellular immunity in hosts, or compromise host defenses by other mechanisms, we …
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The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis
… that endogenous IL-4 does not reduce host immunity. In contrast, IL-4Rα genedeficient mice, which lack both IL-4 and IL-13 signalling, had reduced bacterial burden in the lungs and other organs, increased survival and cellular immunity with macrophage activation. Therefore IL-4Rα …
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The State of T Cell Immunity against Influenza Virus in Humans and Exploration of Potential Strategies to Enhance Cell-Mediated Protection from Influenza Infection
… and previous reports have indicated that cellular immunity is a better correlate of protection than neutralizing antibody titers. However, little is known about the state of influenza-specific cellular immunity in humans. To address this, we examined the CD8 T cell responses of humans of …
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The immune-modulating activity of Sutherlandia frutescens
… of Sutherlandia frutescens on cell mediated immunity was found to be donor specific. Further investigation of Sutherlandia frutescens on cellular immunity is advised.
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Dosage Window of Selenium on Human Natural Killer Cytotoxicity and Neutrophilmediated Chemiluminescence
… of in vitro selenium (Se) supplementation on cellular immunity. In the present study, the effects of in vitro incubation with sodium selenite on natural killer (NK)-mediated cytotoxicity and phagocyte chemiluminescence (CL) were examined. NK-mediated cytotoxicity and phagocyte CL were observed …
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Yeast-based vaccine approaches to cancer immunotherapy
… cells is necessary for successful induction of cellular immunity. Using a yeast vaccine model, we investigated the phagosome-to-cytosol pathway of cross-presentation. We demonstrate that the rate of antigen release from phagocytosed yeast directly affects cross-presentation efficiency, with an …
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Evaluation of the Success of Adoptive Versus Passive Transfer of Immunity Against Trypanosoma Cruzi
… the possible contributions of humoral vs. cellular immunity to the above phenomenon, the relative success of passive transfer of sera and adoptive transfer of whole spleen cells was evaluated. Parasitemias and mortality of donor mice maintained at 21°C or 36°C were monitored. The same …
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Cellular immune mechanisms of psychiatric disorders and the stress response
… a focus on which immune cell subsets, and what cellular mechanisms, might play a causal role in psychiatric symptoms. In this thesis, I use human genetic data, human immunophenotyping and animal models to investigate whether psychiatric disorders and stress are associated with dysfunction in …
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DNA-Launched Vaccines for Emerging and Re-emerging Viral Pathogens
… decrease infection after a single dose however cellular immunity is increased after mice are given the boost dose. These DNA-launched vaccines can combine the benefits of storage, development, and manipulation of DNA, while increasing the immunogenicity, safety profiles of LAVs and subunit …
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Engineering minimally immunogenic cargos and delivery modalities for gene therapy
… have been shown to generate humoral and cellular immunity in the general population. Thus, there is a need for minimally immunogenic cargos and delivery modalities to advance gene therapy to the clinic. The goal of this thesis is to design and optimize minimally immunogenic (1) vehicles …
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