Engineering mesoporous silicon for cell biology applications

Porous Silicon is a material that is made when an electric potential is applied to silicon using a hydrofluoric acid electrolyte. The structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell adhesion. We looked at the potential to use porous silicon as a co-culture by patterning it with patterned regions of different adhesive peptides using a novel lithography method with gold. Next we exploited the high surface area of the material to incorporate small molecules in the structure. Then we used it for cell culture, so that drug releases directly into the cells. We then explored the optical properties of porous silicon to create a stimuli responsive sensor using a composite with a PEG hydrogel. Finally we looked at the potential of topographically modified porous silicon to be used for cell culture

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Materials Science & Engr

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2014

Author dc:creator

• Huang, Tiffany

Contributors dc:contributor

• Kilian, Kristopher A.

• Porous Silicon
• Bioconjugation
• Stem cells
• Optical sensors
• Surface chemistry

Statement dc:rights

• Copyright 2014 Tiffany Huang

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/50464

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/50464