{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/50464"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/50464","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Engineering mesoporous silicon for cell biology applications","abstract":"Porous Silicon is a material that is made when an electric potential is applied to silicon using a hydrofluoric acid electrolyte. The structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell adhesion. We looked at the potential to use porous silicon as a co-culture by patterning it with patterned regions of different adhesive peptides using a novel lithography method with gold. Next we exploited the high surface area of the material to incorporate small molecules in the structure. Then we used it for cell culture, so that drug releases directly into the cells. We then explored the optical properties of porous silicon to create a stimuli responsive sensor using a composite with a PEG hydrogel. Finally we looked at the potential of topographically modified porous silicon to be used for cell culture","abstract_html":"Porous Silicon is a material that is made when an electric potential is applied to silicon using a hydrofluoric acid electrolyte. The structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell adhesion. We looked at the potential to use porous silicon as a co-culture by patterning it with patterned regions of different adhesive peptides using a novel lithography method with gold. Next we exploited the high surface area of the material to incorporate small molecules in the structure. Then we used it for cell culture, so that drug releases directly into the cells. We then explored the optical properties of porous silicon to create a stimuli responsive sensor using a composite with a PEG hydrogel. Finally we looked at the potential of topographically modified porous silicon to be used for cell culture","abstract_has_math":false,"creators":["Huang, Tiffany"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Materials Science & Engr","degree_department":null,"school":null,"contributors":["Kilian, Kristopher A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-09-16T17:17:46Z","date_published":"2014-09-16T17:17:46Z","updated_at":"2026-07-22T22:25:40Z","subjects":["Porous Silicon","Bioconjugation","Stem cells","Optical sensors","Surface chemistry"],"languages":["en"],"rights":["Copyright 2014 Tiffany Huang"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/50464","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kilian, Kristopher A."]},{"key":"dc:creator","label":"Author","values":["Huang, Tiffany"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-09-16T17:17:46Z","2016-09-22T20:59:21Z","2014-08","2014-09-16"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Materials Science & Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Porous Silicon","Bioconjugation","Stem cells","Optical sensors","Surface chemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2014 Tiffany Huang"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/50464"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Porous Silicon is a material that is made when an electric potential is applied to silicon using a hydrofluoric acid electrolyte. The structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell adhesion. We looked at the potential to use porous silicon as a co-culture by patterning it with patterned regions of different adhesive peptides using a novel lithography method with gold. Next we exploited the high surface area of the material to incorporate small molecules in the structure. Then we used it for cell culture, so that drug releases directly into the cells. We then explored the optical properties of porous silicon to create a stimuli responsive sensor using a composite with a PEG hydrogel. Finally we looked at the potential of topographically modified porous silicon to be used for cell culture","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2014-07-16T21:30:21Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Huang_tiffany.docx: 31034068 bytes, checksum: e4b966e184980852e466068d4dde85b8 (MD5) Huang_Tiffany.pdf: 3494089 bytes, checksum: cfeaff37acfea7cb95a16c11b13af0f9 (MD5)","Made available in DSpace on 2014-09-16T17:17:46Z (GMT). No. of bitstreams: 4 Tiffany_Huang.pdf: 3495043 bytes, checksum: 8e1b1821122d42a22f357969982b5ebb (MD5) Huang_tiffany.docx: 31038528 bytes, checksum: e576ae6f03abd9227a4d49f5121b602b (MD5) 1_Huang_tiffany.docx: 31034068 bytes, checksum: e4b966e184980852e466068d4dde85b8 (MD5) license.txt: 4063 bytes, checksum: b01c0496569767f28ef7b5d9c70d6019 (MD5)","Embargo set by: Seth Robbins for item 50575 Lift date: 2016-09-16T17:18:17Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","U of I Only Restriction Lifted for Item 50575 on 2016-09-22T20:59:21Z."]},{"key":"dc:title","label":"Title","values":["Engineering mesoporous silicon for cell biology applications"]}]}],"canonical_facts":{"dc:contributor":["Kilian, Kristopher A."],"dc:creator":["Huang, Tiffany"],"dc:date":["2014-09-16T17:17:46Z","2016-09-22T20:59:21Z","2014-08","2014-09-16"],"dc:description":["Porous Silicon is a material that is made when an electric potential is applied to silicon using a hydrofluoric acid electrolyte. The structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell adhesion. We looked at the potential to use porous silicon as a co-culture by patterning it with patterned regions of different adhesive peptides using a novel lithography method with gold. Next we exploited the high surface area of the material to incorporate small molecules in the structure. Then we used it for cell culture, so that drug releases directly into the cells. We then explored the optical properties of porous silicon to create a stimuli responsive sensor using a composite with a PEG hydrogel. Finally we looked at the potential of topographically modified porous silicon to be used for cell culture","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2014-07-16T21:30:21Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Huang_tiffany.docx: 31034068 bytes, checksum: e4b966e184980852e466068d4dde85b8 (MD5) Huang_Tiffany.pdf: 3494089 bytes, checksum: cfeaff37acfea7cb95a16c11b13af0f9 (MD5)","Made available in DSpace on 2014-09-16T17:17:46Z (GMT). No. of bitstreams: 4 Tiffany_Huang.pdf: 3495043 bytes, checksum: 8e1b1821122d42a22f357969982b5ebb (MD5) Huang_tiffany.docx: 31038528 bytes, checksum: e576ae6f03abd9227a4d49f5121b602b (MD5) 1_Huang_tiffany.docx: 31034068 bytes, checksum: e4b966e184980852e466068d4dde85b8 (MD5) license.txt: 4063 bytes, checksum: b01c0496569767f28ef7b5d9c70d6019 (MD5)","Embargo set by: Seth Robbins for item 50575 Lift date: 2016-09-16T17:18:17Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system","U of I Only Restriction Lifted for Item 50575 on 2016-09-22T20:59:21Z."],"dc:identifier":["http://hdl.handle.net/2142/50464"],"dc:language":["en"],"dc:rights":["Copyright 2014 Tiffany Huang"],"dc:subject":["Porous Silicon","Bioconjugation","Stem cells","Optical sensors","Surface chemistry"],"dc:title":["Engineering mesoporous silicon for cell biology applications"],"dc:type":["text"],"thesis:degree_discipline":["Materials Science & Engr"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:40Z"}