Developmental expression of a 4.5S RNA and variants of U1snRNA in Drosophila melanogaster

Analysis of small RNAs in Drosophila melanogaster revealed the existence of a 4.5S RNA and variants for the U1 snRNA. The 4.5S RNA was separated from other snRNAs by electrophoresis through high percentage polyacrylamide gels. The Drosophila 4.5S RNA migrated at the same rate as the mouse 4.5S$\sb{\rm I}$ RNA standard. Chemical sequence analysis of the 3$\sp\prime$ end of the Drosophila 4.5S RNA revealed a 60% nucleotide homology with the mouse 4.5S$\sb{\rm I}$ RNA. The mouse 4.5S$\sb{\rm I}$ RNA is related to the B$\sb2$ repeat of the mouse genome. The existence and homology of the Drosophila 4.5S RNA to the mouse 4.5S$\sb{\rm I}$ RNA may provide a focal point for the study of the origins of repeated sequences.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Koehler, Richard Fred

Contributors dc:contributor

• Steffensen, D.M.

• Biology, Molecular
• Biology, Genetics

Statement dc:rights

• Copyright 1991 Koehler, Richard Fred

Language dc:language

eng

Identifier

AAI9136639
(UMI)AAI9136639

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/22857