Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"developmental expression"”.
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Developmental expression of a 4.5S RNA and variants of U1snRNA in Drosophila melanogaster
Analysis of small RNAs in Drosophila melanogaster revealed the existence of a 4.5S RNA and variants for the U1 snRNA. The 4.5S RNA was separated from other snRNAs by electrophoresis through high percentage polyacrylamide gels. The Drosophila 4.5S RNA migrated at the same rate as the mouse …
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Developmental Expression of Rat Target of the Antiproliferative Antibody (rTAPA) Protein in the Brain
<p>The present study defines the expression pattern of rTAPA (CD81) in the developing rat brain. rTAPA is a member of the tetramembrane spanning family of proteins, and like other members of this family, appears to be associated with the stabilization of cellular contacts. On immunoblots of the …
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Identification, Characterization, and Developmental Analyses of A Growth Cone Specific Epitope and a Synaptic Vesicle Protein
… 1), a synaptic vesicle antigen (SVP38), and the developmental expression of each in various tissues. Although CD'A 1 and SVP38 do not have any direct relationship to each other, I will show that the expression of both changes over the same time period. This provides a unifying theme for my work. …
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Investigation of isoform-specific fruitless mutants generated by gene targeting in Drosophila melanogaster
… factor isoforms to fulfil a range of developmental and behavioural roles, from the regulation of axonal pathfinding during embryogenesis, all the way to the precise orchestration of individual steps of the Drosophila melanogaster male courtship ritual. Much of the transcriptional …
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Regulation of glycogen phosphorylase genes in Dictyostelium discoideum
… cell differentiation, and aging. A crucial developmental event in Dictyostelium is glycogen degradation. The degradation of glycogen provides glucose monomers that are used to synthesize structural components necessary for cellular differentiation. Glycogen degradation is catalyzed by …
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Growth Differentiation Factor 11 Promotes Survival of Mouse Retinal Ganglion Cells in Vitro through Smad2/3 Activation
… cells (RGCs) to grow dendrites in vitro. The developmental expression pattern of GDF11 in RGCs and the impact of GDF11 on mammalian RGCs remain unknown. The current study investigated 1) the developmental time course of GDF11 expression in RGCs, 2) the effect of GDF11 on RGC survival and …
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Sex-specific expression of CYP2C2 in transgenic mice and phenobarbital regulation of CYP2B by in situ injection
… pattern of this gene in rabbits. Unlike expression in rabbits, the transgene was expressed in a male-specific pattern in liver and kidney, and was undetectable in the female. Expression in the male mice was repressed after castration, while testosterone could partially reverse the …
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Understanding the Conserved and Species-Specific Functions of FOXP2, a Gene Implicated in Speech and Language Development
… regulates evolutionarily distinct subplate gene expression patterns and tested this theory by performing RNA-seq in human differentiating neurons and leveraging publically available developmental expression data from human, macaque, and mouse cortex in order to identify human specific, primate …
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Comparative transcriptomics of long intergenic noncoding RNAs in Drosophila
… These lincRNAs are expressed in every surveyed developmental stage (1st instar larva, 3rd instar larva, pupa, and adult) in both sexes, with a large number increasing in expression as male development proceeds. This male bias can largely be explained by overrepresentation of lincRNAs in the …
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Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine
… the knowledge that age is a major determinant of expression of drug metabolizing enzymes it was hypothesized that age would also impact the expression of drug transporters. The developmental protein expression pattern of the closely related hepatic uptake transporters, OATP1B1 and OATP1B3, was …
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Functional profiles of growth-related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle
… measure myostatin, follistatin, activin-B gene expressions during chicken embryonic development. Strong myostatin expression was found in the early chicken embryos (E 0, E 1) and the developmental expression pattern of myostatin mRNA coincided with the periods of primary and secondary muscle …
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Dynamic visualization and genetic determinants of Sonic hedgehog protein distribution during zebrafish embryonic development
… Hh signaling. In addition, I characterized the developmental expression and function of zebrafish Rab23, a small GTPase, which acts as a negative regulator of the Shh signaling pathway. Performing knock-down experiments of zebrafish Rab23, I found that Rab23 functions in left-right axis …
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Exzitotoxizität im ZNS bei Mausmutanten mit veränderten Glutamatrezeptoren
… performed. Cultured neurons recapitulate the developmental expression profile of the two main NMDA receptor subunits NR2A and NR2B: at 14DIV neurons express NR2B and very low levels of NR2A. At 21DIV, NR2A subunit expression becomes as prominent as the NR2B subunit. In cultured neurons …
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Characterisation of the dead ringer gene of Drosophila melanogaster
… do not resemble a homeo domain. Analysis of the developmental expression pattern of dri showed a ubiquitous maternal deposit gradually refined to localisation in the mesoderm at germ band extension, then further restriction to a diverse set of tissues including the salivary gland ducts, parts of …
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The roles of proteinases and proteinase inhibitors in plant-nematode interactions
… second part of this study, the effects of high expression of proteinase inhibitor I or II transgene on nematode disease development were examined in whole plants grown under greenhouse conditions. It was found that both root galling, nematode egg and egg mass production were inhibited in …
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The Role of Perineuronal Nets in Regulating Barrel Cortex Physiology
… but also regulate plasticity and behavior. Their developmental expression is highly attenuated following sensory deprivation, or pharmacological silencing of neuronal activity. Thus, PNNs contribute to the activity dependent regulation of plasticity in the brain. Although PNNs are relatively …
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Function and evolution of the atypical Notch ligands Dlk1 and Dlk2 during vertebrate development
… targeted deletion results in defects in numerous developmental processes, such as adipogenesis, haematopoiesis, neurogenesis and skeletal muscle formation. However, the mechanisms by which DLK1 regulates these processes remains unclear. The purpose of this project is to examine the function of …
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Analysis of the expression and effects of vascular endothelial growth factor family of molecules on Fragile X Syndrome abnormalities in a mouse model
… factors such as a need for optimized dosage, developmental time for intervention, better metrics for human studies, and most prominently complexity of the mGluR pathway (Scharf et al., 2015). With this ubiquitous failure of mGluR inhibitors, new thrusts have been initiated to determine which …
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Positional Information in Adult Bilaterian Tissues
… (AP) axis. nr4A RNAi caused PCG expression to shift away from the extremes of the AP axis and the iterative duplication of anterior and posterior anatomy. This work reveals a phenotype in which positional information and the cells that influence positional information are no …
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Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… the pivotal role of microRNAs in regulating gene expression during the development and maintenance of the inner ear. These small non-coding RNAs influence key biological processes such as cell differentiation, apoptosis, and oxidative stress, which are essential for maintaining cochlear function …