Pharmacokinetics and renal clearance of morphine and its two major metabolites, morphine-3-glucuronide and morphine-6-glucuronide in the rabbit

The pharmacokinetics of morphine and renal clearance of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and morphine (M) were studied following intravenous (IV) administration of single doses of morphine (1.5 mg/kg) alone, in the presence of cimetidine as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes or in the presence of probenecid as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes. Plasma concentration of M versus time data generated in the present study were analyzed using a bi-exponential equation. The effect of cimetidine and probenecid on the pharmacokinetics of M and renal clearance of M, M3G, and M6G were investigated.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Veterinary Biosciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Davis, Carol Ann

Contributors dc:contributor

• Koritz, Gary D.

• Health Sciences, Pharmacology

Statement dc:rights

• Copyright 1996 Davis, Carol Ann

Language dc:language

eng

Identifier

9780591086829
AAI9702497
(UMI)AAI9702497

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20937