{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20937"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20937","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Pharmacokinetics and renal clearance of morphine and its two major metabolites, morphine-3-glucuronide and morphine-6-glucuronide in the rabbit","abstract":"The pharmacokinetics of morphine and renal clearance of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and morphine (M) were studied following intravenous (IV) administration of single doses of morphine (1.5 mg/kg) alone, in the presence of cimetidine as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes or in the presence of probenecid as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes. Plasma concentration of M versus time data generated in the present study were analyzed using a bi-exponential equation. The effect of cimetidine and probenecid on the pharmacokinetics of M and renal clearance of M, M3G, and M6G were investigated.","abstract_html":"The pharmacokinetics of morphine and renal clearance of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and morphine (M) were studied following intravenous (IV) administration of single doses of morphine (1.5 mg/kg) alone, in the presence of cimetidine as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes or in the presence of probenecid as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes. Plasma concentration of M versus time data generated in the present study were analyzed using a bi-exponential equation. The effect of cimetidine and probenecid on the pharmacokinetics of M and renal clearance of M, M3G, and M6G were investigated.","abstract_has_math":false,"creators":["Davis, Carol Ann"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Veterinary Biosciences","degree_department":null,"school":null,"contributors":["Koritz, Gary D."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:53:37Z","date_published":"2011-05-07T12:53:37Z","updated_at":"2026-07-22T22:25:17Z","subjects":["Health Sciences, Pharmacology"],"languages":["eng"],"rights":["Copyright 1996 Davis, Carol Ann"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["9780591086829","AAI9702497","(UMI)AAI9702497"],"render_values":[{"text":"9780591086829","href":null,"code":true},{"text":"AAI9702497","href":null,"code":true},{"text":"(UMI)AAI9702497","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20937","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Koritz, Gary D."]},{"key":"dc:creator","label":"Author","values":["Davis, Carol Ann"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:53:37Z","10000-01-01","1996"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary Biosciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Pharmacology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1996 Davis, Carol Ann"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["9780591086829","AAI9702497","(UMI)AAI9702497","http://hdl.handle.net/2142/20937"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The pharmacokinetics of morphine and renal clearance of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and morphine (M) were studied following intravenous (IV) administration of single doses of morphine (1.5 mg/kg) alone, in the presence of cimetidine as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes or in the presence of probenecid as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes. Plasma concentration of M versus time data generated in the present study were analyzed using a bi-exponential equation. The effect of cimetidine and probenecid on the pharmacokinetics of M and renal clearance of M, M3G, and M6G were investigated.","After IV administration of morphine a rapid distribution phase (0.1313 $\\pm$ 0.038) was followed by a slower elimination phase (0.0122 $\\pm$ 0.001). The half-life was 53 minutes, Vd$\\rm\\sb{ss}$ was 6.2 L/kg and C1$\\rm\\sb{s}$ was 90 ml/min/kg. The Vd$\\rm\\sb{ss}$ of morphine was reduced in the presence of cimetidine (5.7 L/kg) and in the presence of probenecid (4.8 L/kg). The C1$\\rm\\sb{s}$ was unchanged in the presence of cimetidine (88 ml/min/kg) or probenecid (78 ml/min/kg).","Morphine, M3G and M6G were excreted by the kidney with approximately 27% of the dose recovered in the urine at six hours (M 11%, M3G 15%, M6G, 1%). In the presence of cimetidine, 30% of the dose was recovered (M 6%, M3G 23%, M6G 1%) and in the presence of probenecid, 52W of the dose was excreted (M 19%, M3G 32% and M6G 1%). The redistribution of morphine, by cimetidine, increased the metabolism of morphine and subsequent excretion of more M3G in the urine. With probenecid, redistribution not only enhanced metabolism and excretion of more M3G, but also increased the amount of M excreted.","Renal clearance of M was 12.1 ml/min/kg (filtration and secretion), of M6G was 5.5 ml/min/kg (filtration and secretion), and of M3G was 1.6 ml/min/kg (filtration). Cimetidine, an inhibitor of organic cation renal tubular secretion, partially blocked the secretion of M (7.9 ml/min/kg). Probenecid, an inhibitor of anion renal tubular secretion, blocked the secretion of M6G (3.2 ml/min/kg).","Made available in DSpace on 2011-05-07T12:53:37Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9702497.pdf: 6436195 bytes, checksum: 5df8e91f54788b586e4445735938bc97 (MD5) Previous issue date: 1996","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:47:23Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:21:22-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Pharmacokinetics and renal clearance of morphine and its two major metabolites, morphine-3-glucuronide and morphine-6-glucuronide in the rabbit"]}]}],"canonical_facts":{"dc:contributor":["Koritz, Gary D."],"dc:creator":["Davis, Carol Ann"],"dc:date":["2011-05-07T12:53:37Z","10000-01-01","1996"],"dc:description":["The pharmacokinetics of morphine and renal clearance of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and morphine (M) were studied following intravenous (IV) administration of single doses of morphine (1.5 mg/kg) alone, in the presence of cimetidine as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes or in the presence of probenecid as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes. Plasma concentration of M versus time data generated in the present study were analyzed using a bi-exponential equation. The effect of cimetidine and probenecid on the pharmacokinetics of M and renal clearance of M, M3G, and M6G were investigated.","After IV administration of morphine a rapid distribution phase (0.1313 $\\pm$ 0.038) was followed by a slower elimination phase (0.0122 $\\pm$ 0.001). The half-life was 53 minutes, Vd$\\rm\\sb{ss}$ was 6.2 L/kg and C1$\\rm\\sb{s}$ was 90 ml/min/kg. The Vd$\\rm\\sb{ss}$ of morphine was reduced in the presence of cimetidine (5.7 L/kg) and in the presence of probenecid (4.8 L/kg). The C1$\\rm\\sb{s}$ was unchanged in the presence of cimetidine (88 ml/min/kg) or probenecid (78 ml/min/kg).","Morphine, M3G and M6G were excreted by the kidney with approximately 27% of the dose recovered in the urine at six hours (M 11%, M3G 15%, M6G, 1%). In the presence of cimetidine, 30% of the dose was recovered (M 6%, M3G 23%, M6G 1%) and in the presence of probenecid, 52W of the dose was excreted (M 19%, M3G 32% and M6G 1%). The redistribution of morphine, by cimetidine, increased the metabolism of morphine and subsequent excretion of more M3G in the urine. With probenecid, redistribution not only enhanced metabolism and excretion of more M3G, but also increased the amount of M excreted.","Renal clearance of M was 12.1 ml/min/kg (filtration and secretion), of M6G was 5.5 ml/min/kg (filtration and secretion), and of M3G was 1.6 ml/min/kg (filtration). Cimetidine, an inhibitor of organic cation renal tubular secretion, partially blocked the secretion of M (7.9 ml/min/kg). Probenecid, an inhibitor of anion renal tubular secretion, blocked the secretion of M6G (3.2 ml/min/kg).","Made available in DSpace on 2011-05-07T12:53:37Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9702497.pdf: 6436195 bytes, checksum: 5df8e91f54788b586e4445735938bc97 (MD5) Previous issue date: 1996","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:47:23Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:21:22-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["9780591086829","AAI9702497","(UMI)AAI9702497","http://hdl.handle.net/2142/20937"],"dc:language":["eng"],"dc:rights":["Copyright 1996 Davis, Carol Ann"],"dc:subject":["Health Sciences, Pharmacology"],"dc:title":["Pharmacokinetics and renal clearance of morphine and its two major metabolites, morphine-3-glucuronide and morphine-6-glucuronide in the rabbit"],"dc:type":["text"],"thesis:degree_discipline":["Veterinary Biosciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:17Z"}