Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Probenecid"”.
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Pharmacokinetics and renal clearance of morphine and its two major metabolites, morphine-3-glucuronide and morphine-6-glucuronide in the rabbit
… every thirty minutes or in the presence of probenecid as a loading dose (10 mg/kg) and repeat doses (5 mg/kg) every thirty minutes. Plasma concentration of M versus time data generated in the present study were analyzed using a bi-exponential equation. The effect of cimetidine and probenecid …
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ΠΕΙΡΑΜΑΤΙΚΗ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑΣ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΑΛΛΑ ΦΑΡΜΑΚΑ
… OF PHENYLBUTAZONE OR PHENOBARBITAL, 2. PROBENECID ADMINISTRATION CAN PREVENT THE HEPATOTOXICITY CAUSED: A. BY THE COMBINATION OF "METHOTREXATE AND PHENYLBUTAZONE, B. BY THE COMBINATION OF "METHOTREXATE AND PHENOBARBITAL".
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Kinetics and mechanisms of accumulation for liposomal ciprofloxacin into rat alveolar macrophages
… partly cellular energy-dependent, and involve probenecid-sensitive multidrug resistance proteins (MRPs). Overall, Lipo-CPFX enabled greater drug accumulation into the NR8383 cells than CPFX. This logically suggests a greater potential to treat respiratory infections especially caused by …
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Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
… cells, which could be inhibited by probenecid. Cortisol, glutarate and PAH in the incubation medium also cis-inhibited 3H-PAH uptake, and preincubation with PAH trans-stimulated 3H-PAH uptake. Preliminary studies on human adrenocortical cells also provided evidence for the existence …
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A COMPARISON OF 2D IMAGE ANALYSIS AND DESIGN-BASED STEREOLOGY FOR EVALUATING MORPHOLOGICAL AND ANATOMICAL CHANGES IN THE DOPAMINERGIC SYSTEM OF THE RODENT MIDBRAIN
… rodent models were analyzed; chronic MPTP/probenecid PD (MPD) mouse model, alcohol preferring (AP) rat model, and the enriched environment (EE) rat model. 2D analyses and design-based stereology were used to quantify neuronal number, neuronal volume and regional volume. Student's t-test …
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Sulfotransferase-vermittelte Genotoxizität von benzylischen Metaboliten alkylierter polyzyklischer aromatischer Kohlenwasserstoffe
… Sulfate postuliert, die über Vorbehandlung mit Probenecid vor Verabreichung von 1-HMP und 1-HM-8-MP überprüft wurde. Der Haupteffekt der Probenecid-Behandlung wurde jedoch nicht in der Niere, sondern in der Leber beobachtet, die stark erhöhte Adduktniveaus zeigte. Eine mögliche Erklärung hierfür …
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Novel strategies to enhance bumetanide concentrations in the brain in the treatment of neonatal seizures
… fluid and this concentration increased after probenecid administration. An in vivo model of hypoxic-ischaemic neonatal seizures was established to quantify the pharmacodynamic effect of bumetanide in seizures. OAT3 inhibition enhanced the concentration of bumetanide in the brain in this model. …
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Neuroprotective and immunomodulatory properties of the new PPARγ agonist MDG548: an in vitro and in vivo study in PD models
… the subacute MPTP model and in the chronic MPTP/probenecid (MPTPp) model of PD. MDG548 activity on microglia activation and phenotype was investigated in the substantia nigra pars compacta (SNc) via the evaluation of pro- (TNF-α and iNOS) and anti-inflammatory (CD206) molecules, with fluorescent …
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Characterization of a human renal organic anion transporter
… an approximate Km of 10 µM, and was inhibited by probenecid, dicarboxylates including the probable physiological exchange partner a-ketoglutarate, and the loop diuretics bumetanide and furosemide. Uptake also showed chloride dependence, characteristic of the basolateral organic anion/dicarboxylate …
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Neuronal and Mitochondrial Protection in Chronic Parkinsonism
… week for 5 weeks. MPTP was co-administered with probenecid (250 mg/kg, i.p), an adjuvant that is known to inhibit the peripheral and neuronal clearance of MPTP and potentiate the neurotoxicity of MPTP. The chronic MPD was previously shown to display neurochemical, histological, behavioral and …
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Effects of connexin modulators in animal models of retinal degeneration: delivery and treatment efficacy
… tonabersat) and pannexin channel-blockers (probenecid) in an animal model of oxidative stress and inflammation mimicking the early stages of AMD. The animal model used was the bright light-induced chorio-retinal damage model that has been extensively used as a model of retinal degeneration. …
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Μελέτη της σωληναριακής μεταφοράς του ουρικού οξέος στην πολυκυστική νόσο των ενηλίκων με τη χρήση των δοκιμασιών πυραζιναμίδης και προβενεκίδης
… The renal handling of urate was studied by probenecid and pyrazinamide tests, in 58 patients with adult dominant polycystic kidney disease (ADPKD), 25 with normal renal function and the rest with various degrees of chronic renal failure. The above 58 patients were compared to 21 healthy …