Magnetic resonance diffusion imaging and spectral localization: New methods and their quantitative applications

There has been a growing interest, in recent years, in the measurement of diffusion of water and metabolites in living systems by magnetic resonance (MR) techniques. Knowledge of the diffusion coefficients of the molecules can yield unique information about microstructure and function of tissue. We have developed a method for the measurement of anisotropic diffusion by MR projection reconstruction imaging, which is inherently insensitive to motion artifacts and can have higher signal-to-noise ratio compared with conventional Fourier transform imaging. Anisotropic diffusion of water in skeletal and smooth muscle has been investigated using this method. In addition, the water diffusion coefficient in rat uterus has been correlated to the hormonal level, which suggests that diffusion measurements on the human uterus may be useful in detecting endometrial pathology. We have also developed a method for localized diffusion measurement with efficient acquisition in arbitrarily-shaped regions. Experiments on phantoms and biological tissues have been performed using this method.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biophysics

Grantor

University of Illinois at Urbana-Champaign

Date dc:date

10000-01-01

Author dc:creator

• Yang, Yihong

Contributors dc:contributor

• Lauterbur, Paul C.

• Engineering, Biomedical
• Biophysics, Medical
• Biophysics, General

Statement dc:rights

• Copyright 1995 Yang, Yihong

Language dc:language

eng

Identifier

AAI9543781
(UMI)AAI9543781

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/20528