{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20528"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20528","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Magnetic resonance diffusion imaging and spectral localization: New methods and their quantitative applications","abstract":"There has been a growing interest, in recent years, in the measurement of diffusion of water and metabolites in living systems by magnetic resonance (MR) techniques. Knowledge of the diffusion coefficients of the molecules can yield unique information about microstructure and function of tissue. We have developed a method for the measurement of anisotropic diffusion by MR projection reconstruction imaging, which is inherently insensitive to motion artifacts and can have higher signal-to-noise ratio compared with conventional Fourier transform imaging. Anisotropic diffusion of water in skeletal and smooth muscle has been investigated using this method. In addition, the water diffusion coefficient in rat uterus has been correlated to the hormonal level, which suggests that diffusion measurements on the human uterus may be useful in detecting endometrial pathology. We have also developed a method for localized diffusion measurement with efficient acquisition in arbitrarily-shaped regions. Experiments on phantoms and biological tissues have been performed using this method.","abstract_html":"There has been a growing interest, in recent years, in the measurement of diffusion of water and metabolites in living systems by magnetic resonance (MR) techniques. Knowledge of the diffusion coefficients of the molecules can yield unique information about microstructure and function of tissue. We have developed a method for the measurement of anisotropic diffusion by MR projection reconstruction imaging, which is inherently insensitive to motion artifacts and can have higher signal-to-noise ratio compared with conventional Fourier transform imaging. Anisotropic diffusion of water in skeletal and smooth muscle has been investigated using this method. In addition, the water diffusion coefficient in rat uterus has been correlated to the hormonal level, which suggests that diffusion measurements on the human uterus may be useful in detecting endometrial pathology. We have also developed a method for localized diffusion measurement with efficient acquisition in arbitrarily-shaped regions. Experiments on phantoms and biological tissues have been performed using this method.","abstract_has_math":false,"creators":["Yang, Yihong"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Biophysics","degree_department":null,"school":null,"contributors":["Lauterbur, Paul C."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"10000-01-01","date_published":"10000-01-01","updated_at":"2026-07-22T22:25:16Z","subjects":["Engineering, Biomedical","Biophysics, Medical","Biophysics, General"],"languages":["eng"],"rights":["Copyright 1995 Yang, Yihong"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9543781","(UMI)AAI9543781"],"render_values":[{"text":"AAI9543781","href":null,"code":true},{"text":"(UMI)AAI9543781","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20528","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Lauterbur, Paul C."]},{"key":"dc:creator","label":"Author","values":["Yang, Yihong"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["10000-01-01","2011-05-07T12:41:49Z","1995"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biophysics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Engineering, Biomedical","Biophysics, Medical","Biophysics, General"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1995 Yang, Yihong"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9543781","(UMI)AAI9543781","http://hdl.handle.net/2142/20528"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["There has been a growing interest, in recent years, in the measurement of diffusion of water and metabolites in living systems by magnetic resonance (MR) techniques. Knowledge of the diffusion coefficients of the molecules can yield unique information about microstructure and function of tissue. We have developed a method for the measurement of anisotropic diffusion by MR projection reconstruction imaging, which is inherently insensitive to motion artifacts and can have higher signal-to-noise ratio compared with conventional Fourier transform imaging. Anisotropic diffusion of water in skeletal and smooth muscle has been investigated using this method. In addition, the water diffusion coefficient in rat uterus has been correlated to the hormonal level, which suggests that diffusion measurements on the human uterus may be useful in detecting endometrial pathology. We have also developed a method for localized diffusion measurement with efficient acquisition in arbitrarily-shaped regions. Experiments on phantoms and biological tissues have been performed using this method.","The SLIM (spectral localization by imaging) technique was developed in this group in collaboration with a group at the University of Chicago. This technique has many advantages over the existing spectral localization techniques for in vivo studies. We have applied this technique to the quantitative analysis of regional phosphorus metabolite levels on human brain. The concentrations of the phosphorus metabolites have been measured in regions of human brain, such as cerebrum, cerebellum plus brain stem, and white and grey matter. In order to investigate the reliability of the SLIM technique in in vivo applications, we have developed a Bloch equation-based simulation method to carry out analyses on the combined effects of unavoidable experimental non-idealities and compartmental heterogeneity. For quantitative analysis in surface coil experiments, we have developed an optimized method for flip angle mapping by multiple echo imaging. The flip angle profile obtained from this method was used for compensation of signal intensity variations caused by the inhomogeneous B$\\sb1$ field. Finally, we have developed a method to measure spatially localized 2D correlation spectroscopy (SLIM COSY), which could provide localized in vivo COSY spectra in regions of interest.","Made available in DSpace on 2011-05-07T12:41:49Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9543781.pdf: 3428738 bytes, checksum: 2c4c5deadda0e3b5b8b9996a82cf7c3b (MD5) Previous issue date: 1995","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:44:30Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:19:35-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Magnetic resonance diffusion imaging and spectral localization: New methods and their quantitative applications"]}]}],"canonical_facts":{"dc:contributor":["Lauterbur, Paul C."],"dc:creator":["Yang, Yihong"],"dc:date":["10000-01-01","2011-05-07T12:41:49Z","1995"],"dc:description":["There has been a growing interest, in recent years, in the measurement of diffusion of water and metabolites in living systems by magnetic resonance (MR) techniques. 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Experiments on phantoms and biological tissues have been performed using this method.","The SLIM (spectral localization by imaging) technique was developed in this group in collaboration with a group at the University of Chicago. This technique has many advantages over the existing spectral localization techniques for in vivo studies. We have applied this technique to the quantitative analysis of regional phosphorus metabolite levels on human brain. The concentrations of the phosphorus metabolites have been measured in regions of human brain, such as cerebrum, cerebellum plus brain stem, and white and grey matter. In order to investigate the reliability of the SLIM technique in in vivo applications, we have developed a Bloch equation-based simulation method to carry out analyses on the combined effects of unavoidable experimental non-idealities and compartmental heterogeneity. For quantitative analysis in surface coil experiments, we have developed an optimized method for flip angle mapping by multiple echo imaging. The flip angle profile obtained from this method was used for compensation of signal intensity variations caused by the inhomogeneous B$\\sb1$ field. Finally, we have developed a method to measure spatially localized 2D correlation spectroscopy (SLIM COSY), which could provide localized in vivo COSY spectra in regions of interest.","Made available in DSpace on 2011-05-07T12:41:49Z (GMT). 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