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University of Illinois at Urbana-Champaign
Continuous flow fast atom bombardment and electrospray ionization mass spectrometry in natural products research
Abstract
dc:descriptionContinuous flow fast atom bombardment (CF-FAB) has been applied as a liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) interface in natural products research. Initial studies concentrated on characterization of the interface, optimization of operational parameters and sensitivity assessment. Using a CF-FAB interface, femtomole quantities of different classes of compounds were detected, which is two orders of magnitude more sensitive than by standard FAB. Later, CF-FAB was applied to the analysis of didemnin, streptovaricin, and ecteinascidin mixtures in isocratic and/or gradient modes.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry, Analytical
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2011
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Janota, Katarzyna
- Contributors dc:contributor
-
- Rinehart, Kenneth L., Jr.
Subjects
dc:subject × 1Rights
dc:rights- Statement dc:rights
-
- Copyright 1995 Janota, Katarzyna
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
-
AAI9543611
(UMI)AAI9543611 - OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/20130