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Showing 1 to 20 of 139 for “"electrospray ionization"”.
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Enhanced Electrospray Ionization for Mass Spectrometry and Ion Mobility Spectrometry
Electrospray ionization (ESI) has become one of the most commonly used ionization techniques for mass spectrometry (MS) and ion mobility spectrometry (IMS), and efforts continue to improve its performance. ESI-MS is most recognized for its wide application to biomacromolecules where high …
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Electrospray ionization mass spectrometry for the analysis of proteins and small molecules
… the analysis of proteins and small molecules by Electrospray Ionization Mass Spectrometry (ESI-MS) are discussed. Section I contains an introduction to ESI-MS, including a brief history of mass spectrometry, a discussion of the current theories developed to explain the mechanisms at work during …
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Surfactant Assisted Electrospray Ionization Time of Flight Mass Spectrometry of Synthetic Polymers
… can be used to characterize synthetic polymers. Electrospray Ionization Mass Spectrometry, ESI-MS, is capable of providing a wealth of information on biomolecules, inorganic compounds, and small synthetic polymer (molecular weight less than 3,000 g/mol). While ESI-MS has proven to be a powerful …
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Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)
… and the applications of liquid sample desorption electrospray ionization mass spectrometry (DESI-MS), a new ambient ionization method with focus on the direct analysis of liquid samples. A variety of new applications of liquid sample DESI are discussed in details including protein conformation …
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The Characterisation of Oilfield Chemicals by Electrospray Ionization Multi-Stage Mass Spectrometry (ESI-MSᵑ)
… In the present study, the use of multistage electrospray ionisation ion trap mass spectrometry (ES1-MSᶯ) was investigated for the detection, identification, characterisation and quantification of compounds in both speciality oilfield chemicals (corrosion inhibitors, scale inhibitors, biocides …
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Probing Base Metal Coordination Complexes Using Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry
… more about the reactions that can occur using Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry (ESI QToF MS). This research focuses on Nickel (II) and Iron (III) Nitrate solutions in combination with five ligands: 2,2’-Bipyridine, 4,4’-Bipyridine, …
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Structural Studies on the Estrogen Receptor Ligand Binding Domain Using Electrospray Ionization Mass Spectrometry
A protocol using LC/ESI-MS and LC/ESI-MS/MS was developed and used successfully to identify the site covalent attachment of the photoaffinity label hexestrol diazirine. The application of tandem MS/MS sequencing permitted the identification of several residues near the C-terminus of the protein.
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Continuous flow fast atom bombardment and electrospray ionization mass spectrometry in natural products research
Continuous flow fast atom bombardment (CF-FAB) has been applied as a liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) interface in natural products research. Initial studies concentrated on characterization of the interface, …
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Rapid quantification of trypsin inhibitors in food and feed formulations with electrospray ionization mass spectrometry
… (HMTBA) derived oligo lysine with the help of electrospray ionization mass spectrometry (ESI-MS). HMTBA capped oligo lysine was synthesized through a chymotrypsin catalyzed reaction in phosphate buffer. The developed method was favorably compared with the existing method recommended by American …
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Advancing the characterization of glycan dynamics with in-electrospray ionization hydrogen/deuterium exchange-mass spectrometry.
… traditional HDX when analyzing carbohydrates. In-electrospray ionization (in-ESI HDX-MS) enables rapid labeling and can be applied to study the solvated states of metal-adducted carbohydrates. The goal of this work is to develop in-ESI HDX-MS methods to study carbohydrate dynamics and structures. …
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Pseudo-Molecular Ion Formation by Aromatic Acids in Negative Ionization Mode Electrospray Ionization Mass Spectrometry
… an artifact common to most analyses performed by electrospray ionization mass spectrometry. These species are non-covalent complexes formed between an analyte of interest and any other components (such as mobile phase, additives, and impurities) present in the ionized sample band. Published …
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Investigation of ion transfer efficiency through multi-channel capillaries for a Desorption Electrospray Ionization (DESI) interface
Desorption Electrospray Ionization (DESI) coupled with mass spectrometry (MS) is an efficient imaging technique for obtaining the spatial distribution of molecular species from a surface. In this study, we experimented with different capillary geometries to maximize the signal intensity of analyte …
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From Solution Into the Gas Phase: Studying Protein Hydrogen Exchange and Electrospray Ionization Using Molecular Dynamics Simulation
… contexts. We next use MD to examine the Electrospray ionization (ESI) mechanism of proteins. ESI is a soft ionization technique resulting in the production of gaseous protein ions. The mechanism of ion formation from nanometer sized droplets is unclear. We apply a trajectory stitching MD …
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Evaluation of Ion Transfer Capillary Geometry on Sensitivity of a Desorption Electrospray Ionization and Mass Spectrometry System
… geometry on the sensitivity of the Desorption Electrospray Ionization – Mass Spectrometry (DESI-MS) process. Previous work has shown that heating the ion transfer capillary to 450˚C will improve the resolution of images taken by the DESI-MS owing to increased ion desolvation. This thesis …
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A Deuterium Labeling Method for the Characterization of (Chromophoric) Dissolved Organic Matter Using Ultrahigh Resolution Electrospray Ionization Mass Spectrometry
… (NaBD4) and is analyzed via ultrahigh resolution electrospray ionization (ESI) mass spectrometry. Ketone/aldehyde-containing species (at mass m) in the untreated sample are identified by searching the mass spectrum of the reduced sample for peaks corresponding to deuterated derivatives (at mass …
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Characterization of Cucurbituril Complex Ions in the Gas Phase Using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
… consumption, matrix effects from solvents, etc. Electrospray mass spectrometry has been widely used to investigate host-guest interactions in the gas phase. A particular advantage of gas phase host-guest research is that the experimental results can be directly compared to computational results …
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The determination of β-endosulfan and endosulfan sulfate in human serum with dialkylphosphate metabolites as urinary markers using LC-MS/MS electrospray ionization
… quadrupole mass spectrometer equipped with an electrospray ionization source operating in the negative ionization mode was used for mass detection of all the analytes, employing multiple reaction monitoring as scan mode. Calibration standards and quality control samples for both analyses were …
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Numerical optimization of ion transport in electrospray mass spectrometry
Electrospray ionization (ESI) has developed into a key component of investigative analyses of samples in numerous biological, chemical, and geological contexts due to its unique ability to preserve the structure of ionized species without fragmentation. It is thus important that we fully understand …
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