Fabrication and integration of graphene field effect transistors for advanced biosensing platforms

Since the rise of two-dimensional (2D) nanomaterials such as transition metal dichalcogenides (TMDCs) and graphene derivatives, numerous applications studies have been carried out prompted by the remarkable material properties they have. A variety of investigations have established unique potential of 2D material-based biosensors and bioelectronics using field effect transistors (FETs). Owing to the versatile usage in various biosensing applications with high reproducibility and sensitivity, further investigation on methods that contribute to enhancement of 2D material-based device performance will be critical. To show versatility of a graphene FET device with cellular interfaces, I carried out in vitro study of a non-spontaneous cell-type, skeletal muscle cell (C2C12) using a multi-array graphene FET. In this investigation, I demonstrated simultaneous stimulation and rapid electrical sensing of C2C12 myotubes. Furthermore, assembly and integration of graphene FET with printed circuit board (PCB) and simultaneous imaging capability are explored, to provide an advanced platform for cell/tissue research. Furthermore, to enhance performance of graphene FET for biosensing applications, I present a novel methodology to detect biomolecules using crumpled graphene-based FET. Crumpling approach is compatible with low cost, low power, and scalable fabrication processes and has enhanced sensitivity conferred by its outstanding features such as large surface area to volume ratio, high carrier mobility, and mechanical properties. Here, I introduced a 3D architecturing technique that creates nanoscale crumpling of graphene to reinforce the sensitivity of graphene FET as a biosensor. Reduced Debye screening effect due to the crumpled graphene structures allowed significant improvement of the detection level of graphene to biomolecules. In this investigation, I realized ultrasensitive, label free detection of DNA with 100,000 times improvement of ultimate limit of detection (LOD) compared to a flat graphene device.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Mechanical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2019

Author dc:creator

• Kim, Yerim

Contributors dc:contributor

• Nam, SungWoo

• graphene
• field effect transistor
• biosensing
• DNA
• Skeletal Muscle Cell
• EPS
• Optogenetics
• crumpled

Statement dc:rights

• Copyright 2019 Yerim Kim

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/105271

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/105271