{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/105271"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/105271","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Fabrication and integration of graphene field effect transistors for advanced biosensing platforms","abstract":"Since the rise of two-dimensional (2D) nanomaterials such as transition metal dichalcogenides (TMDCs) and graphene derivatives, numerous applications studies have been carried out prompted by the remarkable material properties they have. A variety of investigations have established unique potential of 2D material-based biosensors and bioelectronics using field effect transistors (FETs). Owing to the versatile usage in various biosensing applications with high reproducibility and sensitivity, further investigation on methods that contribute to enhancement of 2D material-based device performance will be critical. To show versatility of a graphene FET device with cellular interfaces, I carried out in vitro study of a non-spontaneous cell-type, skeletal muscle cell (C2C12) using a multi-array graphene FET. In this investigation, I demonstrated simultaneous stimulation and rapid electrical sensing of C2C12 myotubes. Furthermore, assembly and integration of graphene FET with printed circuit board (PCB) and simultaneous imaging capability are explored, to provide an advanced platform for cell/tissue research. Furthermore, to enhance performance of graphene FET for biosensing applications, I present a novel methodology to detect biomolecules using crumpled graphene-based FET. Crumpling approach is compatible with low cost, low power, and scalable fabrication processes and has enhanced sensitivity conferred by its outstanding features such as large surface area to volume ratio, high carrier mobility, and mechanical properties. Here, I introduced a 3D architecturing technique that creates nanoscale crumpling of graphene to reinforce the sensitivity of graphene FET as a biosensor. Reduced Debye screening effect due to the crumpled graphene structures allowed significant improvement of the detection level of graphene to biomolecules. In this investigation, I realized ultrasensitive, label free detection of DNA with 100,000 times improvement of ultimate limit of detection (LOD) compared to a flat graphene device.","abstract_html":"Since the rise of two-dimensional (2D) nanomaterials such as transition metal dichalcogenides (TMDCs) and graphene derivatives, numerous applications studies have been carried out prompted by the remarkable material properties they have. A variety of investigations have established unique potential of 2D material-based biosensors and bioelectronics using field effect transistors (FETs). Owing to the versatile usage in various biosensing applications with high reproducibility and sensitivity, further investigation on methods that contribute to enhancement of 2D material-based device performance will be critical. To show versatility of a graphene FET device with cellular interfaces, I carried out in vitro study of a non-spontaneous cell-type, skeletal muscle cell (C2C12) using a multi-array graphene FET. In this investigation, I demonstrated simultaneous stimulation and rapid electrical sensing of C2C12 myotubes. Furthermore, assembly and integration of graphene FET with printed circuit board (PCB) and simultaneous imaging capability are explored, to provide an advanced platform for cell/tissue research. Furthermore, to enhance performance of graphene FET for biosensing applications, I present a novel methodology to detect biomolecules using crumpled graphene-based FET. Crumpling approach is compatible with low cost, low power, and scalable fabrication processes and has enhanced sensitivity conferred by its outstanding features such as large surface area to volume ratio, high carrier mobility, and mechanical properties. Here, I introduced a 3D architecturing technique that creates nanoscale crumpling of graphene to reinforce the sensitivity of graphene FET as a biosensor. Reduced Debye screening effect due to the crumpled graphene structures allowed significant improvement of the detection level of graphene to biomolecules. In this investigation, I realized ultrasensitive, label free detection of DNA with 100,000 times improvement of ultimate limit of detection (LOD) compared to a flat graphene device.","abstract_has_math":false,"creators":["Kim, Yerim"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":["Nam, SungWoo"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-08-23T20:48:27Z","date_published":"2019-08-23T20:48:27Z","updated_at":"2026-07-22T22:24:44Z","subjects":["graphene","field effect transistor","biosensing","DNA","Skeletal Muscle Cell","EPS","Optogenetics","crumpled"],"languages":["en"],"rights":["Copyright 2019 Yerim Kim"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/105271","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Nam, SungWoo"]},{"key":"dc:creator","label":"Author","values":["Kim, Yerim"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2019-08-23T20:48:27Z","2021-08-24T09:15:16Z","2019-04-26","2019-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["graphene","field effect transistor","biosensing","DNA","Skeletal Muscle Cell","EPS","Optogenetics","crumpled"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2019 Yerim Kim"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/105271"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Since the rise of two-dimensional (2D) nanomaterials such as transition metal dichalcogenides (TMDCs) and graphene derivatives, numerous applications studies have been carried out prompted by the remarkable material properties they have. A variety of investigations have established unique potential of 2D material-based biosensors and bioelectronics using field effect transistors (FETs). Owing to the versatile usage in various biosensing applications with high reproducibility and sensitivity, further investigation on methods that contribute to enhancement of 2D material-based device performance will be critical. To show versatility of a graphene FET device with cellular interfaces, I carried out in vitro study of a non-spontaneous cell-type, skeletal muscle cell (C2C12) using a multi-array graphene FET. In this investigation, I demonstrated simultaneous stimulation and rapid electrical sensing of C2C12 myotubes. Furthermore, assembly and integration of graphene FET with printed circuit board (PCB) and simultaneous imaging capability are explored, to provide an advanced platform for cell/tissue research. Furthermore, to enhance performance of graphene FET for biosensing applications, I present a novel methodology to detect biomolecules using crumpled graphene-based FET. Crumpling approach is compatible with low cost, low power, and scalable fabrication processes and has enhanced sensitivity conferred by its outstanding features such as large surface area to volume ratio, high carrier mobility, and mechanical properties. Here, I introduced a 3D architecturing technique that creates nanoscale crumpling of graphene to reinforce the sensitivity of graphene FET as a biosensor. Reduced Debye screening effect due to the crumpled graphene structures allowed significant improvement of the detection level of graphene to biomolecules. In this investigation, I realized ultrasensitive, label free detection of DNA with 100,000 times improvement of ultimate limit of detection (LOD) compared to a flat graphene device.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01","The student, Yerim Kim, accepted the attached license on 2019-04-25 at 19:23.","The student, Yerim Kim, submitted this Thesis for approval on 2019-04-25 at 19:32.","This Thesis was approved for publication on 2019-04-26 at 13:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13934 on 2019-08-22 at 16:24:00","Made available in DSpace on 2019-08-23T20:48:27Z (GMT). No. of bitstreams: 2 KIM-THESIS-2019.pdf: 1933698 bytes, checksum: 3fa7dfc9e0f1ef26f642cbfecde5374f (MD5) LICENSE.txt: 4206 bytes, checksum: ceba5521f2efa75fb74b36981c72481f (MD5) Previous issue date: 2019-04-26","Embargo set by: Seth Robbins for item 112393 Lift date: 2021-08-23T20:48:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 112393 on 2021-08-24T09:15:16Z."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Fabrication and integration of graphene field effect transistors for advanced biosensing platforms"]}]}],"canonical_facts":{"dc:contributor":["Nam, SungWoo"],"dc:creator":["Kim, Yerim"],"dc:date":["2019-08-23T20:48:27Z","2021-08-24T09:15:16Z","2019-04-26","2019-05"],"dc:description":["Since the rise of two-dimensional (2D) nanomaterials such as transition metal dichalcogenides (TMDCs) and graphene derivatives, numerous applications studies have been carried out prompted by the remarkable material properties they have. A variety of investigations have established unique potential of 2D material-based biosensors and bioelectronics using field effect transistors (FETs). Owing to the versatile usage in various biosensing applications with high reproducibility and sensitivity, further investigation on methods that contribute to enhancement of 2D material-based device performance will be critical. To show versatility of a graphene FET device with cellular interfaces, I carried out in vitro study of a non-spontaneous cell-type, skeletal muscle cell (C2C12) using a multi-array graphene FET. In this investigation, I demonstrated simultaneous stimulation and rapid electrical sensing of C2C12 myotubes. Furthermore, assembly and integration of graphene FET with printed circuit board (PCB) and simultaneous imaging capability are explored, to provide an advanced platform for cell/tissue research. Furthermore, to enhance performance of graphene FET for biosensing applications, I present a novel methodology to detect biomolecules using crumpled graphene-based FET. Crumpling approach is compatible with low cost, low power, and scalable fabrication processes and has enhanced sensitivity conferred by its outstanding features such as large surface area to volume ratio, high carrier mobility, and mechanical properties. Here, I introduced a 3D architecturing technique that creates nanoscale crumpling of graphene to reinforce the sensitivity of graphene FET as a biosensor. Reduced Debye screening effect due to the crumpled graphene structures allowed significant improvement of the detection level of graphene to biomolecules. In this investigation, I realized ultrasensitive, label free detection of DNA with 100,000 times improvement of ultimate limit of detection (LOD) compared to a flat graphene device.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2021-05-01","The student, Yerim Kim, accepted the attached license on 2019-04-25 at 19:23.","The student, Yerim Kim, submitted this Thesis for approval on 2019-04-25 at 19:32.","This Thesis was approved for publication on 2019-04-26 at 13:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #13934 on 2019-08-22 at 16:24:00","Made available in DSpace on 2019-08-23T20:48:27Z (GMT). No. of bitstreams: 2 KIM-THESIS-2019.pdf: 1933698 bytes, checksum: 3fa7dfc9e0f1ef26f642cbfecde5374f (MD5) LICENSE.txt: 4206 bytes, checksum: ceba5521f2efa75fb74b36981c72481f (MD5) Previous issue date: 2019-04-26","Embargo set by: Seth Robbins for item 112393 Lift date: 2021-08-23T20:48:32Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 112393 on 2021-08-24T09:15:16Z."],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/105271"],"dc:language":["en"],"dc:rights":["Copyright 2019 Yerim Kim"],"dc:subject":["graphene","field effect transistor","biosensing","DNA","Skeletal Muscle Cell","EPS","Optogenetics","crumpled"],"dc:title":["Fabrication and integration of graphene field effect transistors for advanced biosensing platforms"],"dc:type":["text"],"thesis:degree_discipline":["Mechanical Engineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:44Z"}