Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 9619 for “"DNA"”.
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Investigating DNA remodeling in DNA mismatch repair
Many DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these sites, loop DNA between sites, or form oligomers …
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Novel DNA probes for sensitive DNA detection
The ability to detect and interrogate DNA sequences allows further understanding and<br/>diagnosis of genetic disease. The ability to perform such analysis of genetic material<br/>requires highly selective and reliable technologies. Furthermore techniques which can use<br/>simple and cheap …
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DNA-Protein Interactions in f1 DNA Replication
<p>This thesis analyzes the interaction of two DNA-binding proteins with the plus strand replication origin of bacteriophage f1. The origin has a bipartite structure consisting of a required core origin region and an adjacent A+T- rich enhancer sequence that potentiates replication approximately …
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DNA Electronics
DNA is a potential component in molecular electronics. To explore this end, there has been an incredible amount of research on how well DNA conducts and by what mechanism. There has also been a tremendous amount of research to find new uses for it in nanoscale electronics. DNA's self-assembly and …
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Restriction fragment length polymorphism analysis of chloroplast DNA, mitochondrial DNA, and ribosomal DNA in turfgrasses
… length polymorphisms (RFLPs) of chloroplast DNA (cpDNA), mitochondrial DNA (mtDNA), and ribosomal DNA (rDNA), were used to estimate and compare the extent of diversity among the organellar and nuclear genomes, and to infer species relationships. Eight cultivated turfgrass species and …
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DNA repair proteins Metnase and PARP1 regulate DNA integration
DNA integration occurs naturally in various formats and plays important roles in evolution. DNA integration also affects human and animal health. Various genome-editing tools have been developed based on site-specific DNA integration. In mammalian cells, DNA integration is largely random. The …
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Cytotoxicity and DNA cleaving activity of Anti-DNA Autoantibody
"항-DNA 자가항체는 전신성 홍반성 낭창(SLE)의 유발에서 중요한 역할을 수행한다. 하지만 이러한 항체의 자가 면역질환에서의 잠재적인 표적물질과 병리학적인 역할은 아직 명확히 규명되어 있지 않다. 본 연구의 목적은 첫 번째로 항-DNA 자가항체의 DNA-절단 활성과 암세포와 정상세포에서의 세포독성을 분석하고 두 번째로 항체에 의한 세포사멸이 apoptosis를 통해 일어나는지 또한 어떠한 메카니즘이 관여하는지를 밝히고자 하는 것이다. "
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Topologically constrained DNA intercalators: Synthesis and DNA binding studies
The synthesis and DNA binding properties of three macrocyclic diacridines (31, 32 and 33) is discussed. The two acridines are connected by linker chains at the 4- and 9-positions. Macrocycles 31 and 32 are linked via spermine at the 9-position and have been shown to bind to DNA by bisintercalation …
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THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS
… involves the erasure and re-establishment of DNA methylation by both passive and active mechanisms, including DNA repair pathways, and occurs concurrently with an increase in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine …
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DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis
… thesis investigated the relationship between DNA repair mechanisms, aflatoxin B1 (AFB1)-induced DNA damage and carcinogenesis. Mice deficient in 8-oxoguanine glycosylase (OGG1, the rate-limiting enzyme in repair of oxidized guanine), mice heterozygous for OGG1, and wild type mice, were exposed …
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Dithioated Phosphates in DNA Duplex Thermodynamics and Protein-DNA Interactions
Phosphorodithioated DNA contains sulfur atoms at both non-bridging phosphoryl oxygen positions. As an achiral chemical modification of the internucleotide linkage it imparts altered biophysical properties to the phosphate moiety, but still retains normal DNA characteristics such as the ability to …
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Establishing DNA combing to investigate DNA replication stress in vitro
… cell cycle cells faithfully replicate their DNA utilizing multiple DNA replication sites known as origins of replication. DNA is replicated to provide each daughter cell a complete copy of the genome. Replication proceeds bi-directionally from a minority of potential origins licensed for …
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Modifizierte Peptidnucleinsäuren für die sequenzselektive DNA-Spaltung und DNA-Nachweis
… die sequenzselektive Spaltung von Einzelstrang-DNA sowie als Komponenten einer DNA-templatvermittelten Metallkatalyse. Im ersten Projekt konnte durch MALDI-TOF MS und HPLC der Zr(IV)-Komplex des Tris(hydroxymethyl)-aminomethan-PNA-Konjugats (Zr(IV)-15) als aktivste Spezies zur Spaltung …
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Rna-Dna Hybridizations With Dna Immobilized on a Membrane Filter
Made available in DSpace on 2014-12-09T22:04:14Z (GMT). No. of bitstreams: 1 6612335.pdf: 2897014 bytes, checksum: b2309dd0e03a77416d5f56559de7bbeb (MD5) Previous issue date: 1966
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Forensische DNA-Analytik
… Möglichkeiten, die die mitochondriale DNA-Analytik für die Spurenkunde und die Populationsgenetik eröffnet, ausgelotet. Polymorphismen der beiden nichtcodierenden hypervariablen Regionen HV1 und HV2 wurden durch Sequenzierung erschlossen und ergaben zusammen für eine deutsche …
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Selbstassemblierende DNA-Netzwerke
DNA-Netzwerke können als formgebende Muster (Template) zur Funktionalisierung technischer Oberflächen für die bottom-up Materialsynthese Verwendung finden. Zum Aufbau solcher Netzwerke werden synthetisch hergestellte DNA-Oligonukleotide hybridisiert. Im ersten Teil der Arbeit wird ein Weg …
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