Development & testing of ultrasound enhanced prodrug microbubble drug delivery system

Microbubble drug delivery systems vary widely in their design and. This work focused on the application of a novel microbubble system with ultrasound-mediated delivery enhancement via consumer equipment. The work involved the creation of a novel microbubble formulation using a prodrug of Bexarotene to make the exterior layer of the microbubble. This started with development and engineering of productions schemes for stable microbubbles. Physical characterization was done to confirm production and was followed by initial in vitro testing. Results were indicative that microbubbles were formed via the protocol developed, and phantom imaging studies confirmed the enhance contrast from microbubbles for ultrasound imaging. Additionally, the in vitro tests showed enhance effectiveness in drug delivery for C32 cells through multiple assays. Demonstrating the effectiveness of using lipid type prodrugs for the creation of microbubbles and their uses for ultrasound enhanced therapy.

Name thesis:degree_name

M.S.

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Bioengineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2018

Author dc:creator

• Patel, Rushi

Contributors dc:contributor

• Pan, Dipanjan

• Microbubbles
• Drug Delivery

Statement dc:rights

• Copyright 2018 Rushi Patel

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/101741

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/101741