{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/101741"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/101741","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Development & testing of ultrasound enhanced prodrug microbubble drug delivery system","abstract":"Microbubble drug delivery systems vary widely in their design and. This work focused on the application of a novel microbubble system with ultrasound-mediated delivery enhancement via consumer equipment. The work involved the creation of a novel microbubble formulation using a prodrug of Bexarotene to make the exterior layer of the microbubble. This started with development and engineering of productions schemes for stable microbubbles. Physical characterization was done to confirm production and was followed by initial in vitro testing. Results were indicative that microbubbles were formed via the protocol developed, and phantom imaging studies confirmed the enhance contrast from microbubbles for ultrasound imaging. Additionally, the in vitro tests showed enhance effectiveness in drug delivery for C32 cells through multiple assays. Demonstrating the effectiveness of using lipid type prodrugs for the creation of microbubbles and their uses for ultrasound enhanced therapy.","abstract_html":"Microbubble drug delivery systems vary widely in their design and. This work focused on the application of a novel microbubble system with ultrasound-mediated delivery enhancement via consumer equipment. The work involved the creation of a novel microbubble formulation using a prodrug of Bexarotene to make the exterior layer of the microbubble. This started with development and engineering of productions schemes for stable microbubbles. Physical characterization was done to confirm production and was followed by initial in vitro testing. Results were indicative that microbubbles were formed via the protocol developed, and phantom imaging studies confirmed the enhance contrast from microbubbles for ultrasound imaging. Additionally, the in vitro tests showed enhance effectiveness in drug delivery for C32 cells through multiple assays. Demonstrating the effectiveness of using lipid type prodrugs for the creation of microbubbles and their uses for ultrasound enhanced therapy.","abstract_has_math":false,"creators":["Patel, Rushi"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Pan, Dipanjan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018-09-27T16:45:27Z","date_published":"2018-09-27T16:45:27Z","updated_at":"2026-07-22T22:24:40Z","subjects":["Microbubbles","Drug Delivery"],"languages":["en"],"rights":["Copyright 2018 Rushi Patel"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/101741","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pan, Dipanjan"]},{"key":"dc:creator","label":"Author","values":["Patel, Rushi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-09-27T16:45:27Z","2020-09-28T09:15:13Z","2018-05-07","2018-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Microbubbles","Drug Delivery"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2018 Rushi Patel"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/101741"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Microbubble drug delivery systems vary widely in their design and. 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Demonstrating the effectiveness of using lipid type prodrugs for the creation of microbubbles and their uses for ultrasound enhanced therapy.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-08-01","The student, Rushi Patel, accepted the attached license on 2018-05-04 at 12:58.","The student, Rushi Patel, submitted this Thesis for approval on 2018-05-04 at 13:05.","This Thesis was approved for publication on 2018-05-07 at 14:41.","DSpace SAF Submission Ingestion Package generated from Vireo submission #12555 on 2018-09-27 at 11:32:49","Made available in DSpace on 2018-09-27T16:45:27Z (GMT). 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This work focused on the application of a novel microbubble system with ultrasound-mediated delivery enhancement via consumer equipment. The work involved the creation of a novel microbubble formulation using a prodrug of Bexarotene to make the exterior layer of the microbubble. This started with development and engineering of productions schemes for stable microbubbles. Physical characterization was done to confirm production and was followed by initial in vitro testing. Results were indicative that microbubbles were formed via the protocol developed, and phantom imaging studies confirmed the enhance contrast from microbubbles for ultrasound imaging. Additionally, the in vitro tests showed enhance effectiveness in drug delivery for C32 cells through multiple assays. Demonstrating the effectiveness of using lipid type prodrugs for the creation of microbubbles and their uses for ultrasound enhanced therapy.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-08-01","The student, Rushi Patel, accepted the attached license on 2018-05-04 at 12:58.","The student, Rushi Patel, submitted this Thesis for approval on 2018-05-04 at 13:05.","This Thesis was approved for publication on 2018-05-07 at 14:41.","DSpace SAF Submission Ingestion Package generated from Vireo submission #12555 on 2018-09-27 at 11:32:49","Made available in DSpace on 2018-09-27T16:45:27Z (GMT). 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