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Showing 1 to 20 of 75 for “"Microbubbles"”.
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Acoustic biosensing using functionalised microbubbles
In this work, functionalised microbubbles are investigated as a new platform for acoustic biosensing. In medical ultrasound, encapsulated microbubbles (MBs) are injected into the body to enhance contrast between blood and surrounding tissue. Microbubbles are not only good ultrasound scatterers: …
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Nanoparticle-coated polymeric microbubbles for revascularization
… were self-assembled by the amphiphilic polymer. Microbubbles are commonly used as ultrasound contrast agents, and the limited life time of microbubbles is the major challenge for microbubble applications. The coating of the nanoparticles enhanced the microbubbles’ stability, and at the same time, …
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Collapse dynamics of ultrasound contrast agent microbubbles
… the behaviors of single collapsing shelled microbubbles using experimental and theoretical methods. The study of their dynamics is particularly relevant for emerging experimental uses of UCAs which seek to leverage localized mechanical forces to create or avoid specialized biomedical …
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The cleaning of ultrafine coal using microbubbles
… loading and the reduced turbulence around the microbubbles. Various techniques have proven successful in further improving the selectivity by reducing the entrainment and/or entrapment of ash in the froth. To better understand the mechanisms of microbubble flotation, basic information regarding …
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Controllable vapor microbubbles for use in bioparticle actuation
… we present guidelines for using thermally formed microbubbles as a means of fluidic actuation. The use of microbubbles is attractive due to the simple fabrication and operation of such devices, however, prior work in this area was hindered by several issues inherent to vapor bubble formation that …
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Continuous column flotation of ultrafine coal using microbubbles
A flotation column has been developed Incorporating the use of fine air bubbles (less than 100 microns) to remove ash-forming minerals from micronized coal. The microbubble generator used In this work has been characterized and found to yield a very narrow size distribution. Microbubble column …
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A novel method of producing microbubbles for targeted drug delivery.
Microbubbles, currently employed in diagnostic ultrasound as a contrast agent, have a potential new application as vehicles for targeted drug delivery, which could revolutionise medicine by eliminating side-effects. A new device is developed which outperforms all existing devices in terms of …
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Fibrin targeting microbubbles for the detection of nascent surgical adhesions
… This thesis examines the use of fibrin-targeting microbubbles as an ultrasound contrast agent to diagnose peritoneal adhesions. Fibrin targeting is achieved by integrating a CREKA (Cys-Arg-Glu-Lys-Ala) peptide into the microbubble shell. The properties of targeted and non-targeted microbubbles …
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Artificial Micro-Devices: Armoured Microbubbles and a Magnetically Driven Cilium
… of development. Firstly, we study Armoured Microbubbles (AMBs) which can self-propel as artificial microswimmers or facilitate microfluidic mixing in a channel when held stationary on a wall. Secondly, we study an artificial cilium, which due to its unique design, when placed in an array, …
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Design and evaluation of drug loaded microbubbles for ultrasound guided cancer therapy
… new anticancer agents. We succeeded in preparing microbubbles which are able to carry genetic (pDNA, siRNA) and chemotherapeutic (doxorubicin) drugs. We proved that these microbubbles can selectively deliver their genetic or chemotherapeutic drugs to melanoma cells upon ultrasound exposure. We …
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Engineering Microbubbles with the Buried-Ligand Architecture for Targeted Ultrasound Molecular Imaging
Microbubbles are gaseous microspheres stabilized with phospholipid monolayer shells. Because of their compressible gas core, they are highly echogenic. Taking advantage of this property, microbubbles are used as ultrasound contrast agents for signal enhancement. In addition, they are being …
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The Physical Mechanism of Blood-Brain Barrier Opening Using Focused Ultrasound and Microbubbles
… for focused ultrasound (FUS) in conjunction with microbubbles. The physical mechanism behind the opening, however, has not been identified. Insight into the mechanism can be critical for delineating the safety profile for in both small and large animals alike. Therefore the purpose of this …
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Broadband acoustical scattering in coastal environments: application to gelatinous organisms and gas microbubbles
Broadband acoustical technology revolutionized our ability to explore, monitor, and operate in the ocean. While strides have been made in numerous physical and biological applications, there remain many standing scientific questions well suited to broadband approaches. Physics-based sound …
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Passive Acoustic Mapping of Microbubbles in Focused Ultrasound Induced Brain Therapies for Preclinical Studies
Safe and targeted agent delivery to the brain is critical in developing new therapies for highly prevalent brain disorders. Microbubble (MB) - mediated, focused ultrasound (FUS) can temporarily modulate blood-brain barrier permeability (BBBM) to enhance local agent delivery. To explore new brain …
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Microbubbles can remove Listeria monocytogenes from the surface of stainless steels, cucumbers, and avocados
… water) was studied to determine the efficacy of microbubbles at inactivating the pathogen L. monocytogenes on stainless steel and the surface of fresh cucumber and avocado. Stainless steel coupons (1"×2''), cucumber, and avocado surfaces were inoculated with L. monocytogenes (LCDC strain). After …
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Advanced design and experimental validation of MRI contrast agents for fluid pressure mapping using microbubbles
This work is related to monitoring fluid pressure using Magnetic Resonance Imaging or MRI and includes numerical simulations and experimental MRI. The nature of this study is such that techniques other than MRI have been extensively used to assess the contrast agent for its physical behaviour. …
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Application of oxygen microbubbles for groundwater oxygenation to enhance biodegradation of hydrocarbons in soil systems
… the water. This was done by injecting oxygen microbubbles in the soil matrix packed in a 7 ft by 7 ft by 5 inches in width Vertical Slice Test Cell, VSTC, and in a 30-inch column, also packed with sand. Transfer of oxygen to water was monitored after injecting oxygen microbubbles. Compared to …
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Application of oxygen microbubbles for in situ biodegradation of p-xylene contaminated ground water in a soil column
… in a 2.75 inch diameter column using oxygen microbubbles to supply the electron acceptor. One objective was to demonstrate that pxylene can be biodegraded in the soil column and to follow the degradation and pressure drops as a function of time. The next objective was to demonstrate the …
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Development & testing of ultrasound enhanced prodrug microbubble drug delivery system
… engineering of productions schemes for stable microbubbles. Physical characterization was done to confirm production and was followed by initial in vitro testing. Results were indicative that microbubbles were formed via the protocol developed, and phantom imaging studies confirmed the enhance …
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