THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of cytotoxic chemotherapy drugs. It has been reported that >60% of patients receiving chemotherapy suffer from this debilitating condition, which manifests itself in a polyneuropathy of paresthesia, hyperalgesia, allodynia, and numbness, primarily felt in the hands and feet. With no current FDA-approved medications to treat the entirety of CIPN’s symptoms, it is essential to find solutions for this condition. Veering away from classic prescription pharmaceuticals, pharmacological studies have favored medicinal plant–based analgesic therapies, anticipating that these approaches could offer effective pain relief. These preclinical studies have demonstrated the antiallodynic effects of Cannabidiol and Cannabigerol from Cannabis Sativa along with Mitragynine from Mitragyna Speciosa. Not only did they show reduction in mechanical allodynia, but Mitragynine studies showed promise in female-only models. In the present set of experiments, we conduct dose-response studies using both single agents and combinations of these plant alkaloids. These studies were designed to fully evaluate the extent to which these compounds can alleviate mechanical allodynia in a chemotherapy-induced, female-only mouse model. To further emphasize the nature of a female-only preclinical model, we employed a commonly used breast, ovarian, and cervical chemotherapy, taxane, Paclitaxel.

Grantor dc:publisher

Temple University. Libraries

Year dc:date.issued

2025

Author dc:creator

• Ross, Nora Dorothy

Advisor dc:contributor.advisor

• Ward, Sara Jane

Committee members dc:contributor.committeemember

• Rawls, Scott M.
• Langford, Dianne

• Neurosciences
• Cannabigerol
• Cannabinoids
• Chemoinduced peripheral neuropathy
• Kratom
• Mitragynine
• Paclitaxel
• Biomedical sciences

Statement dc:rights

• IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

eng

Repository record dc:identifier.uri

https://scholarshare.temple.edu/handle/20.500.12613/11291

OAI identifier oai:identifier

oai:scholarshare.temple.edu:20.500.12613/11291